Tissue engineering enhanced by the transfer of a growth...

Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S283100, C435S347000, C435S373000

Reexamination Certificate

active

09809456

ABSTRACT:
Tissue engineered constructs including a matrix and cells transfected with a gene for a growth factor. The constructs may be implanted into a tissue site, where the growth factor gene enhances a metabolic function furthering integration of the construct in the tissue site. If the matrix is biodegradable, the metabolic result may include resorption of the matrix and replacement with tissue synthesized at least in part by the transfected cells.

REFERENCES:
patent: 5766585 (1998-06-01), Evans et al.
patent: 5785964 (1998-07-01), Naughton et al.
patent: 5858355 (1999-01-01), Glorioso et al.
patent: 5891455 (1999-04-01), Sittinger et al.
patent: 5932459 (1999-08-01), Sittinger et al.
patent: 6077987 (2000-06-01), Breitbart et al.
Alila, “Expression of Biologically active human insulin-like growth factor-I following intramuscular injection of a formulated plasmid in rats,”Hum Gene Ther8:1785-95, 1997.
Baragi, “Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation,”J Clin Invest96:2454-60, 1995.
Barton-Davis, et al., “Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function,”Proc Natl Acad Sci U S A95:15603-7, 1998.
Bonadio, et al., “Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration,”Nat Med5:753-759, 1999.
Buckwalter, et al., “Articular cartilage repair and transplantation.,”Arthritis Rheum41:1331-1342, 1998.
Doherty, et al., “Resurfacing of articular cartilage explants with genetically-modified human chondrocytes in vitro,”Osteoarthritis Cartilage6:153-9, 1998.
Evans, et al., “Possible orthopaedic applications of gene therapy,”J Bone Joint Surg Am77A:1103-14, 1995.
Eming, et al., “Targeted expression of insulin-like growth factor to human keratinocytes: modification of the autocrine control of keratinocyte proliferation,”J Invest Dermatol107:113-120, 1996.
Farndale, “Improved Quantification of Sulphated Glycosaminoglycans by Use of Dimethylmethylene Blue,”Biochem Biophys Acta, 883: 173-177, 1986.
Frank, et al., “Strearming Potentials: A Sensitive Index of Enzymatic Degradation in Articular Cartilage”,Journal of Orthopaedic Research, 5(4): 497-508, 1987.
Frank, et al., “Cartilage Electromechanics—II. A Continuum Model of Cartilage Electrokinetics and Correlation with Experiments,”J. Biomech, 20: 629-639, 1987.
Freed, et al., “Tissue engineering of cartilage in space,”Proc Natl Acad Sci U S A94:13885-13890, 1997.
Freed, “Chondrogenesis in a cell-polymer-bioreactor system,”Exp Cell Res240:58-65, 1998.
Freed, et al., “Frontiers in Tissue Engineering”, Clinical Orthopaedics and Related Research, 367S: S46-S58.
Ikeda, “Adenovirus mediated gene delivery to the joints of guinea pigs,”J Rheumatol25:1666-73, 1998.
Jansen, “Sequence of cDNA Encoding Human Insulin-Like Growth Factor I Precursor,”Nature, 306: 609-611, 1983.
Kang, “Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: a feasibility study,”Osteoarthritis Cartilage5:139-43, 1997.
Kim, et al., “Fluorometric assay of DNA in cartilage explants using Hoechst 33258,”Anal Biochem174:168-76, 1988.
Kitamura, et al., “Creation of an In vivo cytosensor using engineered mesangial cells. Automatic sensing of glomerular inflammation controls transgene activity,”J Clin Invest100:1394-9, 1997.
Langer, et al., “Tissue Engineering,”Science260:920-926, 1993.
Lauffenburger, et al., “The Matrix Delivers”,Nature Medicine, 5(7): 733-734, 1999.
Madry, et al., “Efficient lipid-mediated gene transfer to articular chondrocytes,”Gene Ther7:286-291, 2000.
Mulligan, “The basic science of gene therapy,”Science260:926-932, 1993.
Nixon, et al., “Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin composites,”J Orthop Res17:475-487, 1999.
O'Driscoll, “The healing and regeneration of articular cartilage,”J Bone Joint Surg Am80A:1795-12, 1998.
Olney, et al., “Production and hormonal regulation of insulin-like growth factor binding proteins in bovine chondrocytes,”Endocrinology133:563-570, 1993.
Peppas, et al., “New Challenges in Biometerials”,Science, 263: 1715-1720, 1994.
Powell, “Tissue-engineered human bioartificial muscles expressing a foregin recombinant protein for gene therapy,”Hum Gene Ther, 10:565-577, 1999.
Saltzman, “Delivering Tissue Regeneration”,Nature Biotechnology, 17: 534-535, 1999.
Smith, “Genetic enhancement of matrix synthesis by articular chondrocytes,”J Rheumatol43:1156-64, 2000.
Trippel, et al., “Characterization of a Specific Somatomedin-c Receptor on Isolated Bovine Growth Plate Chondrocytes,”Endocrinology, 112: 2128-2136, 1983.
Trippel, “Effect of somatomedin-C/insulin-like growth factor I and growth hormone on cultured growth plate and articular chondrocytes,”Pediatr Res25:76-82, 1989.
Trippel, “Growth factor actions on articular cartilage,”J Rheumatol Suppl43:129-32, 1995.
Trippel, “Growth factors as therapeutic agents,”Instr Course Lect46:473-6, 1997.
Vandenburgh, “Tissue-engineered skeletal muscle organoids for reversible gene therapy,”Hum Gene Ther7:2195-2200, 1996.
Vandenburgh, et al., “Attenuation of Skeletal Muscle Wasting with Recombinant Human Growth Hormone Secreted from a Tissue-Engineered Bioartificial Muscle”,Human Gene Therapy, 9:2555-2564, 1998.
Von der Mark, et al., “Relationship Between Cell Shape and Type of Collagen Synthesised as Chondrocytes Lose Their Cartilage Phenotype in Culture”,Nature, 267: 531-532, 1977.
Vunjak-Novakovic, “Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering,”Biotechnol Prog14:193-202, 1998.
Woessner, “The Determination of Hydroxyproline in Tissue and Protein Samples Containing Small Proportions of this Imino Acid,”Arch Biochem Biophys, 93: 440-447, 1961.
Schnabel, et al., Dedifferentiation-associated changes in morphology and gene expression in primary human articular chondrocytes in cell culture,Osteoarthritis and Cartilage(2002) 10 62-70.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Tissue engineering enhanced by the transfer of a growth... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tissue engineering enhanced by the transfer of a growth..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tissue engineering enhanced by the transfer of a growth... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3871723

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.