Tissue engineered tendons and ligaments

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Ligament or tendon

Reexamination Certificate

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Reexamination Certificate

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07914579

ABSTRACT:
Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid copolymers, and seeded with cells isolated from autologous tendon or ligament by means of enzymatic digestion or direct seeding into tissue culture dishes from explants. The cell polymer constructs are then surgically transplanted to replace missing segments of functioning tendon or ligament.

REFERENCES:
patent: 1995970 (1935-03-01), Dorough
patent: 2609347 (1952-09-01), Wilson
patent: 2653917 (1953-09-01), Hammon
patent: 2659935 (1953-11-01), Hammon
patent: 2664366 (1953-12-01), Wilson
patent: 2676945 (1954-04-01), Higgins
patent: 2683136 (1954-07-01), Higgins
patent: 2703316 (1955-03-01), Schneider
patent: 2758987 (1956-08-01), Salzberg
patent: 2846407 (1958-08-01), Wilson
patent: 2951828 (1960-06-01), Zeile et al.
patent: 3531561 (1970-09-01), Trehu
patent: 3826241 (1974-07-01), Bucalo
patent: 3880991 (1975-04-01), Yolles
patent: 3883393 (1975-05-01), Knazek et al.
patent: 3902497 (1975-09-01), Casey
patent: 3935065 (1976-01-01), Doerig
patent: 3949073 (1976-04-01), Daniels et al.
patent: 3960150 (1976-06-01), Hussain et al.
patent: 3974526 (1976-08-01), Dardik et al.
patent: 3992725 (1976-11-01), Homsy
patent: 3995444 (1976-12-01), Clark et al.
patent: 4026304 (1977-05-01), Levy
patent: 4060081 (1977-11-01), Yannas et al.
patent: 4069307 (1978-01-01), Higuchi et al.
patent: 4137921 (1979-02-01), Okuzumi
patent: 4141087 (1979-02-01), Shalaby et al.
patent: 4144126 (1979-03-01), Burbidge
patent: 4186448 (1980-02-01), Brekke
patent: 4192827 (1980-03-01), Mueller et al.
patent: 4205399 (1980-06-01), Shalaby et al.
patent: 4228243 (1980-10-01), Iizuka
patent: 4239664 (1980-12-01), Teng et al.
patent: 4243775 (1981-01-01), Rosensaft et al.
patent: 4277582 (1981-07-01), Mueller et al.
patent: 4280954 (1981-07-01), Yannas et al.
patent: 4304591 (1981-12-01), Mueller et al.
patent: 4304866 (1981-12-01), Green et al.
patent: 4328204 (1982-05-01), Wasserman et al.
patent: 4347847 (1982-09-01), Usher
patent: 4348329 (1982-09-01), Chapman
patent: 4352883 (1982-10-01), Lim
patent: 4356261 (1982-10-01), Kuettner
patent: 4391797 (1983-07-01), Folkman et al.
patent: 4416986 (1983-11-01), Markus et al.
patent: 4427808 (1984-01-01), Stol et al.
patent: 4431428 (1984-02-01), Schmer
patent: 4438198 (1984-03-01), Schmer
patent: 4439152 (1984-03-01), Small
patent: 4440921 (1984-04-01), Allcock et al.
patent: 4444887 (1984-04-01), Hoffmann
patent: 4446229 (1984-05-01), Indech
patent: 4446234 (1984-05-01), Russo et al.
patent: 4450150 (1984-05-01), Sidman
patent: 4456687 (1984-06-01), Green
patent: 4458678 (1984-07-01), Yannas et al.
patent: 4485096 (1984-11-01), Bell
patent: 4485097 (1984-11-01), Bell
patent: 4489056 (1984-12-01), Himmelstein et al.
patent: 4494385 (1985-01-01), Kuraoka et al.
patent: 4495174 (1985-01-01), Allcock et al.
patent: 4505266 (1985-03-01), Yannas et al.
patent: 4520821 (1985-06-01), Schmidt et al.
patent: 4528265 (1985-07-01), Becker
patent: 4544516 (1985-10-01), Hughes et al.
patent: 4545082 (1985-10-01), Hood
patent: 4553272 (1985-11-01), Mears
patent: 4559298 (1985-12-01), Fahy
patent: 4559304 (1985-12-01), Kasai et al.
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4563490 (1986-01-01), Stol et al.
patent: 4576608 (1986-03-01), Homsy
patent: 4595713 (1986-06-01), St. John
patent: 4609551 (1986-09-01), Caplan et al.
patent: 4627853 (1986-12-01), Campbell et al.
patent: 4637931 (1987-01-01), Schmitz
patent: 4642120 (1987-02-01), Nevo et al.
patent: 4645669 (1987-02-01), Reid
patent: 4675189 (1987-06-01), Kent et al.
patent: 4675284 (1987-06-01), Leevy et al.
patent: 4713070 (1987-12-01), Mano
patent: 4721096 (1988-01-01), Naughton et al.
patent: 4734373 (1988-03-01), Bartal
patent: 4757017 (1988-07-01), Cheung
patent: 4757128 (1988-07-01), Domb et al.
patent: 4778749 (1988-10-01), Vasington et al.
patent: 4846835 (1989-07-01), Grande
patent: 4853324 (1989-08-01), Viles et al.
patent: 4868121 (1989-09-01), Scharp et al.
patent: 4880622 (1989-11-01), Allcock et al.
patent: 4891225 (1990-01-01), Langer et al.
patent: 4946938 (1990-08-01), Magill et al.
patent: 4963489 (1990-10-01), Naughton et al.
patent: 4988761 (1991-01-01), Ikada et al.
patent: 5019087 (1991-05-01), Nichols
patent: 5032508 (1991-07-01), Naughton et al.
patent: 5041138 (1991-08-01), Vacanti et al.
patent: 5078744 (1992-01-01), Chvapil
patent: 5092887 (1992-03-01), Gendler
patent: 5171273 (1992-12-01), Silver et al.
patent: 5263984 (1993-11-01), Li et al.
patent: 5306311 (1994-04-01), Stone et al.
patent: 5376118 (1994-12-01), Kaplan et al.
patent: 5595621 (1997-01-01), Light et al.
patent: 5681353 (1997-10-01), Li et al.
patent: 5696175 (1997-12-01), Mikos et al.
patent: 5716404 (1998-02-01), Vacanti et al.
patent: 6027743 (2000-02-01), Khouri et al.
patent: B-24245/88 (1989-02-01), None
patent: 2853614 (1979-07-01), None
patent: 3518150 (1986-10-01), None
patent: 0153896 (1985-09-01), None
patent: 0 226 061 (1987-06-01), None
patent: 0248246 (1987-12-01), None
patent: 0248247 (1987-12-01), None
patent: 0 282 746 (1988-09-01), None
patent: 0 339 607 (1989-11-01), None
patent: 62-11459 (1987-01-01), None
patent: 63074498 (1988-04-01), None
patent: 63196273 (1988-08-01), None
patent: 63196595 (1988-08-01), None
patent: WO 87/06120 (1987-10-01), None
patent: WO 88/03785 (1988-06-01), None
patent: WO 89/00413 (1989-01-01), None
patent: WO 89/07944 (1989-08-01), None
patent: WO 90/12603 (1990-11-01), None
patent: WO 90/12604 (1990-11-01), None
patent: WO 92/07525 (1992-05-01), None
patent: WO 93/08850 (1993-05-01), None
patent: WO 93/17913 (1993-09-01), None
patent: WO 94/21299 (1994-09-01), None
patent: WO 94/25079 (1994-11-01), None
Allcock et al., “Synthesis of Poly[(Amino Acid Alkyl Ester)Phosphazenes]”Macromolecules10(4):824-830 (1977).
Allcock et al., “Hydrolysis Pathways for Aminophosphazenes”Inorg. Chem. 21(1):515-521 (1982).
Allcock et al., “Amphilphilic Polyphosphazenes as Membrane Materials: Influence of Side Group on Radiation Cross Linking,”Biomaterials9(6):500-508 (1988).
Allcock et al., “Phosphonitrilic Compounds. IV. High Molecular Weight Poly[bis(amino)phosphazenes] and Mixed-Substituent Poly(aminophosphazenes),”Inorg. Chem. 11(11):2584-2590 (1972).
Allcock et al., “Polyphosphazenes with Etheric Side Groups; Prospective Biomedical and Solid Electrolyte Polymers”Macromolecules19:1508-1512 (1986).
Allcock and Kwon, “An Ionically Cross-Linkable Polyphosphazene: Poly[bis(carboxylatophenoxy)phosphazene] and Its Hydrogels and Membranes”Macromolecules22:75-79 (1989).
Allcock and Kwon, “Glyceryl Phosphazenes: Synthesis, Properties, and Hydrolysis”Macromolecules21(7):1980-1985 (1988).
Allcock and Scopelianos, “Synthesis of Sugar Substituted Cyclic and Polymeric Phosphazenes and Their Oxidation, Reduction, and Acetylation Reactions”Macromolecules16(5):715-719 (1983).
Anderson et al., “Gene Expression in Implanted Rat Hepatocytes Following Retroviral-Mediated Gene Transfer”Somatic Cell and Mol. Gen. 15(3):215-227 (1989).
Anderson, Caltech Biology (1987).
Alberts et al., Molecular Biology of the Cell, Garland Publishing, Inc., pp. 893-894.
Atala et al., “Endoscopic Treatment of Vesicoureteral Reflux with a Chondrocyte-Alginate Suspension”J. Urology152:641-643 (1994).
Atala et al., “Endoscopic Treatment of Vesicoureteral Reflux with a Self-detachable Balloon System”J. Urology148:724-728 (1992).
Atala et al., “Injectable Alginate Seeded with Chondrocytes as a Potential Treatment for Vesicoureteral Reflux”J. Urology150:745-747 (1993).
Atala et al., “Laparoscopic Correction of Vesicoureteral Reflux”J. Urology150:748-751 (1993).
Atala et al., “Sonography with Sonicated Albumin in the Detection of Vesidoureteral Reflux”J. Urology150:756-758 (1993).
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