Tissue engineered tendons and ligaments

Details Tissue engineered tendons and ligaments Tissue engineered tendons and ligaments

1997-08-04

2000-09-26

Isabella, David J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

Ligament or tendon

A61F 208

Patent

active

061237272

ABSTRACT:
Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid copolymers, and seeded with cells isolated from autologous tendon or ligament by means of enzymatic digestion or direct seeding into tissue culture dishes from explants. The cell polymer constructs are then surgically transplanted to replace missing segments of functioning tendon or ligament.

REFERENCES:
patent: 4576608 (1986-03-01), Homsy
patent: 5019087 (1991-05-01), Nichols
patent: 5078744 (1992-01-01), Chvapil
patent: 5092887 (1992-03-01), Gendler
patent: 5171273 (1992-12-01), Silver
patent: 5263984 (1993-11-01), Li et al.
patent: 5376118 (1994-12-01), Kaplan et al.

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