Tissue engineered cellular sheets, and methods of making same

Details Tissue engineered cellular sheets, and methods of making same Tissue engineered cellular sheets, and methods of making same

2009-03-17

2011-12-13

Ketter, Jim (Department: 1636)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Solid support and method of culturing cells on said solid...

C435S325000, C435S366000, C623S001130, C623S001140

Reexamination Certificate

active

08076137

ABSTRACT:
The disclosure provides methods and compositions to build living tissue covered stents and the like. These tissue coated stents provide a barrier against cell migration to the lumen of the vessel. Since the tissue can surround and envelope the stent, foreign body responses to the stent material are reduced and delayed. The tissue coating is also relatively impermeable to transmural flow, so the wrapped stent can act as a bypass vessel. The tissue is also robust enough to act as a stand alone vessel, without requiring the presence of the metallic stent. These stents can be endothelialized to reduce thrombosis. The genetic modifications described in this disclosure allow for functional organs to be built that express agents that are anti-restenotic or anti-thrombogenic.

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