Tissue engineered blood vessels and apparatus for their...

Details Tissue engineered blood vessels and apparatus for their... Tissue engineered blood vessels and apparatus for their...

2006-09-26

2006-09-26

Barrett, Thomas (Department: 3738)

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Having living cell

C623S001100

Reexamination Certificate

active

07112218

ABSTRACT:
The invention is a tissue engineered blood vessel (TEBV) made from a cultured fibroblast sheet rolled into a multilayer vessel which has sufficient burst strength to withstand physiological blood pressure without the inclusion of smooth muscle cells or synthetic scaffolding. The TEBV is made in a bioreactor having an enclosed chamber, a sheet growth module, a rollable mandrel, and a clamp for holding the sheet to the mandrel for rolling.

REFERENCES:
patent: 4441215 (1984-04-01), Kaster
patent: 4546500 (1985-10-01), Bell
patent: 5618718 (1997-04-01), Auger et al.
patent: 5628786 (1997-05-01), Banas et al.
“A Completely Biological Tissue-Engineered Human Blood Vessel,” L'Heureux, N., et al., FASEB Journal, 12:47-56, Jan. 1998.

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