Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Reexamination Certificate
2007-05-08
2007-05-08
Wehbe′, Anne M. (Department: 1633)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
C424S093100, C424S489000, C424S484000, C424S488000, C435S325000, C435S366000
Reexamination Certificate
active
09654276
ABSTRACT:
The invention is directed to tissue-engineered biografts, methods for preparing the biografts of the invention, and methods for repairing a damaged myocardium in a mammal. The methods of the invention can include providing a three-dimensional porous polysaccharide matrix; introducing mammalian cells into said matrix; growing said cells in said matrix in vitro, until a tissue-engineered biograft is formed; and transplanting the tissue-engineered biograft onto myocardial tissue or myocardial scar tissue of said mammal. The tissue-engineered biograft of the invention can form a contracting tissue. The methods of the invention can optionally include removing scar tissue or dead tissue from the site of implantation prior to transplanting the biograft.
REFERENCES:
patent: 5494682 (1996-02-01), Cohen et al.
patent: 6099832 (2000-08-01), Mickle et al.
patent: 97/44070 (1997-11-01), None
patent: WO 97/44070 (1997-11-01), None
patent: 99/03973 (1999-01-01), None
patent: WO 99/03973 (1999-01-01), None
patent: 99/65463 (1999-12-01), None
Kaufmann et al., Xenotransplantation, 1995, Annu. Rev. Immunol., vol. 13, pp. 339-367.
Leor et al., Abstracts selected for the presentation at the XXIst Congress of the European Society of Cardiology, Aug. 28-Sep. 1, 1999, Barcelona Spain, 1999, European Heart Journal, vol. 20, Abstract.
Li et al., Survival and function of bioengineered cardiac grafts, 1999, Circulation, vol. 100(suppl. II) II-63-II-69.
Cohen, et al., “Controlled Delivery Systems For Proteins Based On Poly (Lactic/Glycolic Acid) Microspheres”Pharmaceutical Research, vol. 8, No. 6, pp. 713-720, 1991.
Kanter, et al., “Distinct Patterns of Connexin Expression In Canine Purkinje Fibers And Ventricular Muscle”Circ. res., vol. 72, No. 5, May 1993.
Leor, et al., “Transplantation of Fetal Myocardial Tissue Into The Infracted Myocardium Of Rat”Circulation 94, Suppl, II, pp. 332-336, Nov. 1996.
Li, et al., “Survival And Function Of Bioengineereed Cardiac Grafts”Circulation 19, pp. 1163-1169, Nov. 1999.
Shapiro & Cohen, “Novel Alginate Sponges For Cell Culture and Transplantation”Biomaterials, vol. 18, No. 8, pp. 583-590, 1997.
Taylor, et al., “Regenerating Functional Myocardium: Improved Performance After Skeletal Myoblast Transplantation”Nature Medicine, vol. 4, No. 8, pp. 929-933, Aug. 1998.
Horrigan et al., 1996,Circulation, 94(8):1927-1933 “Coronary Heart Disease/Myocardial Infarction: Reduction in Myocardial Infarct Size by Basic Fibroblast Growth Factor After Temporary Coronary Occlusion in a Canine Model”.
Itskovitz-Eldor et al., 2000,Molecular Medicine, 6(2):88-95 “Differentiation of Human Embryonic Stem Cells into Embryoid Bodies Comprising the Three Embryonic Germ Layers”.
Rowley et al., 1999,Biomaterials, 20:45-53 “Alginate hydrogels as synthetic extracellular matrix material”.
Thomson et al., 1998,Science, 282:1145-1147 “Embryonic Stem Cell Lines Derived from Human Blastocysts”.
Tomita et al., 1999,Circulation, 100(Suppl. II):II-247-II-256 “Autollogous Transplantation of Bone Marrow Cells Improves Damaged Heart Function”.
Wobus et al., 1991,Differentiation, 48:173-182 “Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing chronotropic responses to adrenergic and cholinergic agents and Ca2+channel blockers”.
Superdock et al., 1993,Seminars in Respiratory Infections, 8(3):152-159 “Immunosuppressive Drugs and Their Effects”.
Woodley et al., 1990,Cardiology Clinics, 8(1):83-96 “Immunosuppression Following Cardiac Transplantation”.
Li et al., 1999,Circulation, 100(supp. II):II-63-II-69 “Survival and Function of Bioengineered Cardiac Grafts.”
Cohen Smadar
Dar Ayelet
Etzion Sharon
Leor Jonathan
Perets Anat
Ben-Gurion University of the Negev Research & Development A
Merchant & Gould P.C.
Wehbe′ Anne M.
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