Tissue destruction in cryosurgery by use of thermal hysteresis

Details Tissue destruction in cryosurgery by use of thermal hysteresis Tissue destruction in cryosurgery by use of thermal hysteresis

1996-03-29

1997-08-05

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 606 20, 606 21, 128DIG27, A61K 3802, A61K 3817, A61B 1736

Patent

active

056542798

ABSTRACT:
Cell and tissue destruction by cryoablation is enhanced by the perfusion of the cells with thermal hysteresis proteins prior to the cryogenic freezing. The effect of the proteins is to promote the growth of spicular ice crystals in the intracellular fluid which destroy the cell by piercing the cell membrane. This decreases the incidence of cell preservation by freezing, thereby permitting a more uniform and controllable destruction of undesirable tissue by the cryoablation technique.

REFERENCES:
patent: 4531373 (1985-07-01), Rubinsky
patent: 5147355 (1992-09-01), Friedman et al.
patent: 5358931 (1994-10-01), Rubinsky et al.
patent: 5437673 (1995-08-01), Raust et al.
patent: 5531742 (1996-07-01), Barken
Gary M. Onik, "Ultrasound-Guided Cryosurgery," Scientific American Science & Medicine, Jan./Feb. 1996, pp. 62-71.

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