Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1995-06-07
1999-02-16
Scheiner, Laurie
Drug, bio-affecting and body treating compositions
Lymphokine
424 852, 514 2, 514 12, A61K 4505
Patent
active
058717242
ABSTRACT:
The present invention provides a method for inhibiting cytotoxic poisoning of normal cells in a subject which comprises administering to the subject an amount of a Transforming Growth Factor Beta effective to slow the growth of normal cells and thereby inhibit the cytotoxic poisoning of the normal cells in the subject. Typically, administration is topical and initiated prior to anti-neoplastic therapy such as radiation treatment or chemotherapy. The invention is particularly suited for pediatric patients.
REFERENCES:
patent: 4863902 (1989-09-01), Amagase et al.
patent: 4929442 (1990-05-01), Powell
patent: 5199942 (1993-04-01), Gillis
patent: 5278145 (1994-01-01), Keller et al.
Brown et al. (1986) "Enhancement of Epidermal Regeneration By Biosynthetic Epidermal Growth Factor", Journal of Experimental Medicine 163: 1319-1324.
Cheifetz et al. (1987) "The Transforming Growth Factor-.beta. System, a Complex Pattern of Cross-Reactive Ligands and Receptors," Cell 48: 409-415.
Epstein et al. (1988) "The Painful Mouth", Infectious Disease Clinics of North America 2: 183-202.
Gabrilove et al. (1988) "Effect of Granulocyte Colony-Stimulating Factor", New England Journal of Medicine 318: 1414-1422.
Jacobsen et al. (1991) "Bidirectional Effects of Transforming Growth Factor .beta. (TGF-.beta.) on colony-Stimulating Factor-Induced Human Myelopoiesis In Vitro: Differential Effects of Distinct TGF-.beta. Isoforms," Blood 78(9): 2239-2247.
Konturek et al. (1981) "Gastric Cytoprotection by Epidermal Growth Factor," Gastroenterology 81: 483-443.
Lawrence et al. (1984) "Reversal of an Adriamycin Induced Healing Impairment with Chemoattractants and Growth Factors," Ann. Surg 203:142-147.
Niall et al. (1982) "The Effect of Epidermal Growth Factor on Wound Healing in Mice," Journal of Surgical Research 33: 164-169.
Peterson et al. (1982) "Oral Complications of Cancer Chemotherapy: Present Status and Future Studies", Cancer Treatment Reports 66: 1251-1256.
Robinson et al. (1985) "Epidermal Growth Factor (hEGF) Has No Effect on Murine Intestine Epithelial Damage and Regeneration After Melphalan", Br. J. Cancer 52: 733-737.
Rosa et al. (1988) "Mesoderm Induction in Amphibians: The Role of TGF-.beta.2-Like Factors," Science 239: 783-785.
Sonis et al. (1990) "An Animal Model for Mucositis Induced by Cancer Therapy", Oral Surg. Oral Med. Oral Pathol. 69: 437-443.
Sonis et al. (1992) "Effect of Epidermal Growth Factor on Ulcerative Muscositis in Hamsters that Receive Cancer Chemotherapy", Oral Surg. Oral Med. Oral Pathol. 74: 749-755.
Southgate et al. (1987) "Primary Culture of Human Oral Epithelial Cells", Laboratory Investigation 56: 211-223.
Steidler et al. (1980) "Histomorphological Effects of Epidermal Growth Factor on Skin and Oral Mucosa in Neonatal Mice", Archives of Oral Biology 25: 37-43.
Takehara, K. et al. (1987) "TGF-.beta. Inhibition of Endothelial Cell Proliferation: Alteration of EGF Binding and EGF-Induced Growth-Regulatory (Competence) Gene Expression", Cell 49:415-422.
Roberts et al., PNAS, vol. 82, pp. 119-123, Jan. 1985.
Miller et al., NY Acad. Sci. 0(0) pp. 208-217 1990, Conference on the Betas In 1989.
Dijke Peter Ten
Foulkes J. Gordon
Haley John D.
Iwata Kenneth K.
O.S.I. Pharmaceuticals Inc.
Scheiner Laurie
White John P.
LandOfFree
Tissue-derived tumor growth inhibitors, methods of preparation a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Tissue-derived tumor growth inhibitors, methods of preparation a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tissue-derived tumor growth inhibitors, methods of preparation a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2059606