Tissue-derived tumor growth inhibitors, methods of preparation a

Drug – bio-affecting and body treating compositions – Lymphokine

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514 12, 514 21, 530351, 530399, A61K 3819, A61K 3818, C07K 14475, C07K 14495

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058242970

ABSTRACT:
The present invention provides a method for inhibiting cytotoxic poisoning of normal cells in a subject which comprises administering to the subject an amount of a Transforming Growth Factor Beta effective to slow the growth of normal cells and thereby inhibit the cytotoxic poisoning of the normal cells in the subject. Typically, administration is topical and initiated prior to anti-neoplastic therapy such as radiation treatment or chemotherapy. The invention is particularly suited for pediatric patients.

REFERENCES:
patent: 4863902 (1989-09-01), Amagase et al.
patent: 4929442 (1990-05-01), Powell
patent: 4931548 (1990-06-01), Lucas et al.
patent: 5037643 (1991-08-01), Green
patent: 5104979 (1992-04-01), Sporn et al.
patent: 5108989 (1992-04-01), Amonto et al.
patent: 5135915 (1992-08-01), Czarniecki et al.
patent: 5199942 (1993-04-01), Gillis
patent: 5236905 (1993-08-01), Braukovan et al.
patent: 5262319 (1993-11-01), Iwata et al.
patent: 5278145 (1994-01-01), Keller et al.
Brown et al. (1986) "Enhancement of Epidermal Regeneration By Biosynthetic Epidermal Growth Factor", Journal of Experimental Medicine 163: 1319-1324.
Epstein et al. (1988) "The Painful Mouth", Infectious Disease Clinics of North America 2: 183-202.
Gabrilove et al. (1988) "Effect of Granulocyte Colony-Stimulating Factor", New England Journal of Medicine 318: 1414-1422.
Konturek et al. (1981) "Gastric Cytoprotection by Epidermal Growth Factor", Gastroenterology 81: 438-443.
Lawrence et al. (1984) "Reversal of an Adriamycin Induced Healing Impairment with Chemoattractants and Growth Factors", Ann. Surg. 203: 142-147.
Niall et al. (1982) "The Effect of Epidermal Growth Factor on Wound Healing in Mice", Journal of Surgical Research 33: 164-169.
Peterson et al. (1982) "Oral Complications of Cancer Chemotherapy: Present Status and Future Studies", Cancer Treatment Reports 66:1251-1256.
Robinson et al. (1985) "Epidermal Growth Factor (hEGF) Has No Effect on Murine Intestine Epithelial Damage and Regeneration After Melphalan", Br. J. Cancer 52: 733-737.
Sonis et al. (1990) "An Animal Model for Mucositis Induced by Cancer Therapy", Oral Surg. Oral Med. Oral Pathol. 69: 437-443.
Sonis et al. (1992) "Effect of Epidermal Growth Factor on Ulcerative Muscositis in Hamsters that Receive Cancer Chemotherapy", Oral Surg. Oral Med. Oral Pathol. 74: 749-755.
Southgate et al. (1987) "Primary Culture of Human Oral Epithelial Cells", Laboratory Investigation 56: 211-223.
Steidler et al. (1980) "Histomorphological Effects of Epidermal Growth Factor on Skin and Oral Mucosa in Neonatal Mice", Archives of Oral Biology 25: 37-43.
Takehara et al. (1987) "TGF-.beta. Inhibition of Endothelial Cell Proliferation: Alteration of EGF Binding and EGF-Induced Growth-Regulatory (Competence) Gene Expression", Cell 49: 415-422.
Sporn et al. "Transforming Growth Factor-.beta. : Biological Function & Chemical Structure" Science 233: 532-534 1986.
Miller et al. NY Acad Sci. 0(0) pp. 208-217 1990 From Conference on THF .beta. in 1989.
Roberts et al. "Type .beta. Transforming Growth Factor: A Bifunctional Regulator of Cellular Growth" Proc. Natl. Acad. Aci 82 119-123 1985.

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