Tissue adhering compositions

Details Tissue adhering compositions Tissue adhering compositions

2007-12-21

2011-10-11

Russel, Jeffrey E (Department: 1654)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S486000, C514S001100, C514S021920, C606S214000

Reexamination Certificate

active

08034367

ABSTRACT:
A method mixes a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material comprising poly(ethylene glycol) having a functionality of at least three. The second component includes a nucleophilic material comprising a natural or synthetic protein at a concentration of about 25% or less that, when mixed with the first component within a reaction pH range, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material includes tris-hydroxymethylaminomethane having a pH within the reaction pH range. The method applies the mixture to adhere to a tissue region.

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West JL et al Proteolytically Degradable Hydrogels Apr. 30-May 4, 1997 23rdAnnual Meeting of the Society for Biomaterials New Orleans Louisiana.

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