Timothy grass antigen specific anti-idiotypic antibodies

Details Timothy grass antigen specific anti-idiotypic antibodies Timothy grass antigen specific anti-idiotypic antibodies

1982-06-22

1985-10-08

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 424 91, 514 2, 260112R, 260112B, 435 68, 435240, 435241, A61K 39395, A61K 3936, A61K 3702, C07G 700, C12P 200, C12N 500, C12N 502

Patent

active

045459860

ABSTRACT:
This invention provides a number of immunological reagents useful for the suppression of allergic reactions induced by Timothy-grass pollen allergen (or cross-reacting allergens thereof) and for methods of obtaining said reagents. The reagents include: (1) an anti-idiotypic antibody (anti-IgE.sub.id) directed to the allergen (Timothy grass antigen) binding site of an IgE immunoglobulin; (2) an anti-idiotypic antibody directed to the allergenic T-cell helper factor (T.sub.HF) derived from Timothy grass pollen antigen stimulated lymphocytes; (3) unique methods for generating antigen-specific T-suppressor cells (T.sub.S); (4) a unique method for producing antigen-specific suppressor T cell factors (T.sub.SF); (5) a method for fractionation of T.sub.SF ; and (6) a specific T cell factor, T.sub.SF2. The invention further provides pharmaceutical compositions comprising the above anti-idiotypic antibodies or suppressor factor derived from T.sub.s cells.

REFERENCES:
Malley, A., and Deppe, L., Int. Arch. Allergy Appl. Immun., vol. 63, pp. 113-120, 1980.
Malley et al., Immunology, vol. 45, pp. 217-225, 1982.
Malley et al., "Induction and Characterization of Suppressor T Cells and Soluble Factors with Modified Timothy Grass Pollen AgB", International Archives of Allergy and Applied Immunology, vol. 65, pp. 129-151 (1981).
Blaser et al., "Suppression of Anti-Hapten IgE and IgG Antibody Responses by Isologous Anti-Idiotypic Antibodies Against Purified Anti-Carrier (Ovalbumin) Antibodies in BALB/c Mice", Journal of Immunology, vol. 126, pp. 1180-1184 (Mar. 1981).

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