Time-staggered utilization of tumor cells in combination...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...

Reexamination Certificate

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C424S130100, C424S138100, C424S154100, C424S155100, C424S156100, C424S277100, C424S093700, C530S387300, C530S388850

Reexamination Certificate

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06994853

ABSTRACT:
The invention relates to the time-staggered utilization of tumor cells in combination with intact, preferably heterologous antibodies for the immunization of humans and animals.

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Lindhofer et al, Annual meeting international society for experimental hematology XX, XX, 1997, 25:879, abstract 527.
Multihoff et al (Int. J. Cancer 61:272-279, 1995).
Campbell et al., “The role of tumor rejection antigens in host antitumor defense mechanisms,”Cancer(1995) 75(11): 2649-55.
Lindhofer et al., “Bispecific antibodies target operationally tumor-specific antigens in two leukemia relapse models,”Blood1996) 88(2): 4651-58.
Lindhofer et al., “Bispecific antibodies effectively purge cancer cells from peripheral blood stem cell collections without affecting colony forming units,” Annual Meeting International Society for Experimental Hematology, XX, XX (1997) 25(8): 879.

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