Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2011-03-08
2011-03-08
Le, Long V (Department: 3768)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
Reexamination Certificate
active
07904140
ABSTRACT:
A time-resolved fluorescence device is described for the detection and diagnosis of various metabolic diseases in a noninvasive or minimally invasive manner. The device uses an ultra-short excitation pulse that comprises of a repetition of nanosecond pulses. The excitation pulse is directed incident onto a strategically selected area of the patient body such as the forearm, the feet, and the palm. This light interacts with the different layers of the skin. The absorbed light excites conditions of interest in the skin, which in turn generate a fluorescence signal, which is collected by a detector. A processor is coupled to the detector to measure the transient fluorescence intensity decay of the skin in terms of lifetimes, and the contribution of individual fluorophores to the overall fluorescence signal.
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Katika Kamal M.
Pilon Laurent G.
Le Long V
O'Banion John P.
Selkin Saurel J
The Regents of the University of California
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