Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-01-25
2005-01-25
Kemmerer, Elizabeth (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S091500
Reexamination Certificate
active
06846640
ABSTRACT:
The present invention provides for a polypeptide aggregation screening assay for the purpose of detecting modulators of polypeptide aggregation, which can provide for new therapies in pathologic states associated with polypeptide aggregation, especially considered is Alzheimer's Disease.
REFERENCES:
patent: 5721106 (1998-02-01), Maggio et al.
patent: 5817626 (1998-10-01), Findeis et al.
patent: 5837473 (1998-11-01), Maggio et al.
patent: 5854215 (1998-12-01), Findeis et al.
patent: 6319498 (2001-11-01), Findeis et al.
patent: WO 9808868 (1998-03-01), None
patent: WO 9906545 (1999-02-01), None
patent: WO 9906838 (1999-02-01), None
Ross (Aug. 29, 2002) “Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's diseases and related disorders.” Neuron 35(5):819-822.*
Tobin & Signer (Dec. 2000) “Huntington's disease: the challenge for cell biologists.” Trends Cell Biol. 10(12):531-536.*
Sipe (1992) “Amyloidosis” Annu. Rev. Biochem. 61: 947-975.*
Akikusa et al., “Practical assay and molecular mechanism of aggregation inhibitors of β-amyloid,”J. Pept. Res.,61:1-6 (2003).
Hetenyi et al., “Pentapeptide Amides Interfere with the Aggregation of β-Amyloid Peptide of Alzheimer's Disease,”Biochemical and Biophysical Research Communications, 292:931-936 (2002).
Howlett et al., “Inhibition of fibril formation in β-amyloid peptide by a novel series of benzofurans,”Biochem. J.,340:283-280 (1999).
Hughes et al., “β2-macroglobulin associates with β-amyloid peptide and prevents fibril formation,”Proc. Natl. Acad. Sci. USA,95:3275-3280 (1998).
Watanabe et al., “Inhibitors of Fibril Formation and Cytotoxicity of β-Amyloid Peptide Composed of KLVFF Recognition Element and Flexible Hydrophilic Disrupting Element,”Biochemical and Biophysical Research Communications, 290:121-124 (2002).
Allsop et al.,Biochem. Biophy. Res. Comm.,285:58-63 (2001).
Azriel et al.,J. Biol. Chem.,276:34156-161 (2001).
Berthelier et al.,Anal. Biochem.,295:227-236 (2001).
Cane et al.,Science, 282:63-68 (1998).
Citron et al.,Nature, 360:672-674 (1992).
Davies P.,Annals of the N.Y. Acad. of Sci., 924:8-16 (2000).
Findeis et al.,Biochemistry,38:6791-6800 (1999).
Haas et al.,Nature, 359:322-325 (1992).
Howlett et al.,FEBS Letters, 417:249-251 (1997).
Iwatsubo et al.,Neuron., 13:45 (1994).
Kang et al.,Nature, 325:733-736 (1987).
Kitaguchi et al.,Nature, 331:530-532 (1988).
Lannfelt et al.,Neurosci. Lett., 153:85-87 (1993).
Lowe et al.,Biochemistry, 40:7882-89 (2001).
Myers,Curr. Opin. Biotechnol., 8:701-707 (1997).
Perutz and Windle,Nature, 412:143-144 (2001).
Ponte et al.,Nature, 331:525-527 (1988).
Schenk et al.,Nature, 400:173-177 (1999).
Seubert et al.,Nature, 359:325-327 (1992).
Tanzi et al.,Nature, 331:528-530 (1988).
Yan et al.,Nature, 402:533-537 (1999).
Laborde Alice L.
Peach Matthew L.
Kemmerer Elizabeth
Nichols Christopher James
Pharmacia & Upjohn Company
Pharmacia & Upjohn Company
Wootton Thomas A.
LandOfFree
Time-resolved fluorescence assay for the detection of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Time-resolved fluorescence assay for the detection of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Time-resolved fluorescence assay for the detection of... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3380134