Time-of-flight mass spectrometry analysis of biomolecules

Details Time-of-flight mass spectrometry analysis of biomolecules Time-of-flight mass spectrometry analysis of biomolecules

1999-07-13

2000-05-02

Anderson, Bruce C.

Radiant energy

Ionic separation or analysis

Methods

250287, 250423P, B01D 5944, H01J 4900

Patent

active

060575433

ABSTRACT:
A time-of-flight mass spectrometer for measuring the mass-to-charge ratio of a sample molecule is described. The spectrometer provides independent control of the electric field experienced by the sample before and during ion extraction. Methods of mass spectrometry utilizing the principles of this invention reduce matrix background, induce fast fragmentation, and control the transfer of energy prior to ion extraction.

REFERENCES:
patent: 3727047 (1973-04-01), Janes
patent: 4072862 (1978-02-01), Mamyrin et al.
patent: 4076982 (1978-02-01), Ritter et al.
patent: 4295046 (1981-10-01), Gruter et al.
patent: 4296322 (1981-10-01), Wechsung
patent: 4330208 (1982-05-01), Eloy
patent: 4405860 (1983-09-01), Brunnee et al.
patent: 4431924 (1984-02-01), Suovaniemi et al.
patent: 4447546 (1984-05-01), Hirschfeld
patent: 4542987 (1985-09-01), Hirschfeld
patent: 4595496 (1986-06-01), Carson
patent: 4611118 (1986-09-01), Managadze
patent: 4620103 (1986-10-01), Kambara et al.
patent: 4625112 (1986-11-01), Yoshida
patent: 4694168 (1987-09-01), Le Beyec et al.
patent: 4730111 (1988-03-01), Vestal et al.
patent: 4731532 (1988-03-01), Frey et al.
patent: 4731533 (1988-03-01), Vestal
patent: 4733073 (1988-03-01), Becker et al.
patent: 4740692 (1988-04-01), Yamamoto et al.
patent: 4766312 (1988-08-01), Fergusson et al.
patent: 4814612 (1989-03-01), Vestal et al.
patent: 4839143 (1989-06-01), Vora et al.
patent: 4861989 (1989-08-01), Vestal et al.
patent: 4862753 (1989-09-01), Lovette et al.
patent: 4866279 (1989-09-01), Schelten et al.
patent: 4883958 (1989-11-01), Vestal
patent: 4894536 (1990-01-01), Conzemius
patent: 4902891 (1990-02-01), Vestal
patent: 4904872 (1990-02-01), Grix et al.
patent: 4918316 (1990-04-01), Schelten
patent: 4951214 (1990-08-01), Hollister
patent: 4958529 (1990-09-01), Vestal
patent: 4960992 (1990-10-01), Vestal et al.
patent: 4988879 (1991-01-01), Zare et al.
patent: 4999493 (1991-03-01), Allen et al.
patent: 5015845 (1991-05-01), Allen et al.
patent: 5017780 (1991-05-01), Kutscher et al.
patent: 5032722 (1991-07-01), Boesl et al.
patent: 5041725 (1991-08-01), Izumi
patent: 5045694 (1991-09-01), Beavis et al.
patent: 5065018 (1991-11-01), Bechtold et al.
patent: 5070240 (1991-12-01), Lee et al.
patent: 5083020 (1992-01-01), Takahashi
patent: 5118937 (1992-06-01), Hillenkamp et al.
patent: 5135870 (1992-08-01), Williams et al.
patent: 5144127 (1992-09-01), Williams et al.
patent: 5160840 (1992-11-01), Vestal
patent: 5175430 (1992-12-01), Enke et al.
patent: 5180914 (1993-01-01), Davis et al.
patent: 5191212 (1993-03-01), Falk et al.
patent: 5200614 (1993-04-01), Jenkins
patent: 5202563 (1993-04-01), Cotter et al.
patent: 5210412 (1993-05-01), Lewis et al.
patent: 5227628 (1993-07-01), Turner
patent: 5233189 (1993-08-01), Wollnik
patent: 5234838 (1993-08-01), Bacon, Jr.
patent: 5245185 (1993-09-01), Busch et al.
patent: 5281538 (1994-01-01), Cottrell et al.
patent: 5283199 (1994-02-01), Bacon, Jr. et al.
patent: 5288644 (1994-02-01), Beavis et al.
patent: 5300774 (1994-04-01), Buttrill, Jr.
patent: 5331158 (1994-07-01), Dowell
patent: 5338931 (1994-08-01), Spangler et al.
patent: 5365063 (1994-11-01), Kaesdorf et al.
patent: 5367162 (1994-11-01), Holland et al.
patent: 5376788 (1994-12-01), Standing et al.
patent: 5382793 (1995-01-01), Weinberger et al.
patent: 5396065 (1995-03-01), Myerholtz et al.
patent: 5438518 (1995-08-01), Bianco et al.
patent: 5464985 (1995-11-01), Cornish et al.
patent: 5498545 (1996-03-01), Vestal
patent: 5504326 (1996-04-01), Reilly et al.
patent: 5510613 (1996-04-01), Reilly et al.
patent: 5563410 (1996-10-01), Mullock
patent: 5572035 (1996-11-01), Franzen
patent: 5580733 (1996-12-01), Levis et al.
patent: 5594243 (1997-01-01), Weinberger et al.
patent: 5614711 (1997-03-01), Li et al.
patent: 5625184 (1997-04-01), Vestal et al.
patent: 5627369 (1997-05-01), Vestal et al.
patent: 5652427 (1997-07-01), Whitehouse et al.
patent: 5654543 (1997-08-01), Li
patent: 5654544 (1997-08-01), Dresch
patent: 5654545 (1997-08-01), Holle et al.
patent: 5659170 (1997-08-01), Da Silveira et al.
patent: 5661300 (1997-08-01), Hansen et al.
patent: 5665967 (1997-09-01), Coxon et al.
patent: 5696375 (1997-12-01), Park et al.
patent: 5708268 (1998-01-01), Franzen
patent: 5712479 (1998-01-01), Reilly et al.
patent: 5739529 (1998-04-01), Laukien et al.
patent: 5739530 (1998-04-01), Franzen et al.
patent: 5744797 (1998-04-01), Park
patent: 5753909 (1998-05-01), Park et al.
Wiley et al., "Time-of-Flight Mass Spectrometer with Improved Resolution," The Review of Scientific Instruments, vol. 26, No. 12, 1150-1157 (1955).
Mamyrin et al., "The Mass-Reflectron, a New Nonmagnetic Time-of-Flight Mass Spectrometer with High Resolution," Sov. Phys.--JETP, vol. 37, No. 1, Jul. 1973, 45-48.
Igersheim et al., "Time-of-Flight Mass Spectrometers with Particle Guides," Int'l. J. of Mass Spec. and Ion Physics, 20(1976)77-88 (copy of certification of translation).
Van Breemen et al., "Time-Resolved Laser Desorption Mass Spectrometry," Int'l. J. of Mass Spec. and Ion Physics, 49(1983)35-50.
Tabet et al., "Laser Desorption Time-of-Flight Mass Spectrometry of High Mass Molecules," Anal. Chem., 1984, 56, 1662.
Cotter et al., "Structural Determination of Lipid A from Gram Negative Bacteria Using Laser Desorption Mass Spectrometry," Biomedical and Environmental Mass Spec., vol. 14, 591-598 (1987).
Demirev et al., "High-Mass Ion Fragmentation as a Function of Time and Mass," Anal. Chem., 1987, 59, 1951-1954.
Glashchenko et al., "Spatial-Temporal Focusing of Ions Extracted from an Extended Ionization Region," Sov. Phys. Tech. Phys. 32(6), Jun. 1987, 665-667.
Heller et al., "Mass Spectral Analysis of Complex Lipids Desorbed Directly from Lyophilized Membranes and Cells," Biochemical and Biophysical Research Communications, vol. 142, No. 1, 1987, 194-199.
Karas et al., "Matrix-Assisted Ultraviolet Laser Desorption of Non-Volatile Compounds," Int'l. J. of Mass Spec. and Ion Processes, 78(1987)53-68.
El-Sayed et al., "Kinetic Energy of Fragment Ions by Pulsed Laser-Pulsed Extraction Field Technique and the Mechanism of Laser Multiphoton Ionization Dissociation: 2,4-Hexadiyne," J. Phys. Chem., 1988, 92, 5333-5337.
Grix et al., "A Time-of-Flight Mass Analyzer with High Resolving Power," Rapid Communications in Mass Spectrometry, vol. 2, No. 5, 1988.
Loo et al., "State-Resolved Photofragment Velocity Distributions by Pulsed Extraction Time-of-Flight Mass Spectrometry," J. Phys. Chem., 1988, 92, 5-8.
Cotter, "Time-of-Flight Mass Spectrometry: An Increasing Role in the Life Sciences," Biomed. Environ. Mass Spectrum. 18(1989) 513.
Kinsel et al., "Post Source Pulse Focusing: A Simple Method to Achieve Improved Resolution in a Time-of-Flight Mass Spectrometer," Int'l. J. of Mass Spec. and Ion Processes, 91 (1989) 157-176.
Erickson et al., "Mass Dependence of Time-Lag Focusing in Time-of-Flight Mass Spectrometry--An Analysis," Int'l. J. of Mass Spec. and Ion Processes, 97 (1990) 87-106.
Spengler et al., "Ultraviolet Laser Desorption/Ionization Mass Spectrometry of Proteins above 100000 Daltons by Pulsed Ion Extraction Time-of-Flight Analysis," Anal. Chem., vol. 62, No. 8, Apr. 15, 1990, 793-796.
Spengler et al., "Infrared Laser Desorption Mass Spectrometry of Oligosaccharides: Fragmentation Mechanisms and Isomer Analysis," Anal. Chem., 1990, vol. 62, No. 17, 1731-1737.
Spengler et al., "Molecular Weight Determination of Underivatized Oligodeoxyribonucleotides by Positive-Ion Matrix-Assisted Ultraviolet Laser-Desorption Mass Spectrometry," Rapid Comm. in Mass Spec., vol. 4, No. 4, 1990, 99-102.
Jacobson et al., "Applications of Mass Spectrometry to DNA Sequencing," Gata 8(8):223-229, 1991.
Jacobson et al., "An Approach to the Use of Stable Isotopes for DNA Sequencing," Genomics, 9, 51-59 (1991).
Kutscher et al., "A Transversally and Longitudinally Focusing Time-of-Flight Mass Spectrometer," Int'l. J. of Mass Spec. and Ion Processes, 103 (1991) 117-128.
Boesl et al., "Reflectron Time-of-Flight Mass Spectrometry and Laser Excitation of the Analysis of Neutrals, Ionized Molecules and Secondary Fragments," Int'l.

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