Time-delay integration in electrophoretic detection systems

Optics: measuring and testing – By electrophoresis

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07468793

ABSTRACT:
An apparatus for detecting analytes in a sample is provided. The apparatus includes: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with non-coherent radiation; a detector array disposed for collecting light signals emitted from markers in the detection zone excited by the radiation, the detector array having an output; and a system coupled to the detector array for effecting time delay integration of the charges on the detector array corresponding to the light signals by accumulating the charges before reading the charges at the output of the detector array. Other apparatus and methods for detecting analytes in a sample are also provided.

REFERENCES:
patent: 4832815 (1989-05-01), Kambara et al.
patent: 4833332 (1989-05-01), Robertson et al.
patent: 4931223 (1990-06-01), Bronstein et al.
patent: 5091652 (1992-02-01), Mathies et al.
patent: 5141609 (1992-08-01), Sweedler et al.
patent: 5173748 (1992-12-01), Bilhorn
patent: 5188934 (1993-02-01), Menchen et al.
patent: 5192412 (1993-03-01), Kambara et al.
patent: 5268080 (1993-12-01), Kambara et al.
patent: 5277780 (1994-01-01), Kambara
patent: 5314602 (1994-05-01), Kambara et al.
patent: 5366608 (1994-11-01), Kambara
patent: 5388860 (1995-02-01), Brede et al.
patent: 5439578 (1995-08-01), Dovichi et al.
patent: 5470710 (1995-11-01), Weiss et al.
patent: 5529679 (1996-06-01), Takahashi et al.
patent: 5582705 (1996-12-01), Yeung et al.
patent: 5627643 (1997-05-01), Birnbaum et al.
patent: 5636017 (1997-06-01), Bruno et al.
patent: 5667656 (1997-09-01), Kambara
patent: 5674442 (1997-10-01), Morita
patent: 5675155 (1997-10-01), Pentoney et al.
patent: 5695626 (1997-12-01), Yeung et al.
patent: 5710628 (1998-01-01), Waterhouse et al.
patent: 5717602 (1998-02-01), Kenning
patent: 5730850 (1998-03-01), Kambara et al.
patent: 5741411 (1998-04-01), Yeung et al.
patent: 5741412 (1998-04-01), Dovichi et al.
patent: 5754291 (1998-05-01), Kain
patent: 5784157 (1998-07-01), Gorfinkel et al.
patent: 5790727 (1998-08-01), Dhadwal et al.
patent: 5833826 (1998-11-01), Nordman
patent: 5833827 (1998-11-01), Anazawa et al.
patent: 5847162 (1998-12-01), Lee et al.
patent: 5885778 (1999-03-01), Menchen et al.
patent: 5936087 (1999-08-01), Benson et al.
patent: 6005663 (1999-12-01), Waterhouse et al.
patent: 6008379 (1999-12-01), Benson et al.
patent: 6017434 (2000-01-01), Simpson et al.
patent: 6020481 (2000-02-01), Benson et al.
patent: 6025505 (2000-02-01), Lee et al.
patent: 6051719 (2000-04-01), Benson et al.
patent: 6084667 (2000-07-01), Melman et al.
patent: 6110683 (2000-08-01), Reynolds et al.
patent: 6140048 (2000-10-01), Müller et al.
patent: 6249341 (2001-06-01), Basiji et al.
patent: 6404495 (2002-06-01), Melman et al.
patent: 6529275 (2003-03-01), Amirkhanian et al.
patent: 6690467 (2004-02-01), Reel
patent: 0 616 211 (1994-09-01), None
patent: WO 88/04777 (1988-06-01), None
patent: WO 95/11961 (1995-05-01), None
patent: WO 95/23348 (1995-08-01), None
patent: WO 97/19342 (1997-05-01), None
patent: WO 97/45539 (1997-12-01), None
patent: WO 98/12536 (1998-03-01), None
patent: WO 00/25113 (2000-05-01), None
European Search Report, mailed Dec. 14, 2004, for European Application No. 02 75 6697 (3 pages).
Altria, Capillary electrophoresis,Royal Society of Chemistry, 7 Sheets, (2000).
Brochure, Charge-Coupled Devices for Quantitative Electronic Imaging,Photometrics, Ltd, pp. 1-3, and 6-17, (1992).
Bronstein,Anal. Biochemistry, 219:169-81 (1993).
Charge-Coupled Devices for Quantitative Electronic Imaging, Photometrics Ltd., (1992).
Genome Sequencing Center, Washington University School of Medicine St. Louis, MO USA,EST&GSS Projects, http://genome.wustl.edu/est/est—general/trace—intro.html., (Monday, Mar. 26, 2001).
Grossman, Factors Affecting the Performance of Capillary Electrophoresis Separations: Joule Heating, Electroosmosis, and Zone Dispersion,Academic Press, Inc,, pp. 3, 24, 28, and 38, (1992).
Karger et al., Multiwavelength fluorescence detection for DNA sequencing using capillary electrophoresis,Nucleic Acids Research, vol. 19, No. 18, pp. 4955-4962, (Jul. 29, 1991).
Kostichka et al., High Speed Automated DNA Sequencing in Ultrathin Slab Gels,Bio/Technology, vol. 10, pp. 78-81, (Jan. 1992).
Kricka, Nonisotopic DNA Probe Techniques,Academic Press, San Diego, pp. 3-28, (1992).
Novotny, Capillary electrophoresis,Current Opinion in Biotechnology, vol. 7, pp. 29-34 (1996).
Reel,Camera Lens Spectrograph Optics Design for MegaGUT, pp. 1-42, (Jan. 16, 1997).
Ross et al., High Sensitivity is Key to CE Detection Boost,Today's Chemist at Work, Vo. 6(8), pp. 31-32, 34 and 36, (Sep. 1997).
Sanger et al., DNA Sequencing with Chain Terminating Inhibitors, 74Proc. Nat. Acad. Sci. USA, 5463, (1977).
Simpson et al., A transmission imaging spectrograph and microfabricated channel system for DNA analysis,Electrophoresis 2000, vol. 21, pp. 135-149 (2000).
Smith et al., Fluorescence detection in automated DNA sequence analysis, 321Nature674, (1986).
Smith et al., The Future of DNA sequencing, 262Science530, (1993).
Sweedler et al., Fluorescence Detection in Capillary Zone Electrophoresis Using a Charge-Coupled Device with Time-Delayed Integration,Analytical Chemistry, vol. 63, No. 5, pp. 496-502, (Mar. 1, 1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Time-delay integration in electrophoretic detection systems does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Time-delay integration in electrophoretic detection systems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Time-delay integration in electrophoretic detection systems will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4038325

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.