Time-delay integration in electrophoretic detection systems

Details Time-delay integration in electrophoretic detection systems Time-delay integration in electrophoretic detection systems

2005-02-15

2005-02-15

Stafira, Michael P. (Department: 2877)

Optics: measuring and testing

By electrophoresis

Reexamination Certificate

active

06856390

ABSTRACT:
An apparatus for detecting analytes in a sample is provided. The apparatus includes: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with non-coherent radiation; a detector array disposed for collecting light signals emitted from markers in the detection zone excited by the radiation, the detector array having an output; and a system coupled to the detector array for effecting time delay integration of the charges on the detector array corresponding to the light signals by accumulating the charges before reading the charges at the output of the detector array. Other apparatus and methods for detecting analytes in a sample are also provided.

REFERENCES:
patent: 4832815 (1989-05-01), Kambara et al.
patent: 4833332 (1989-05-01), Robertson et al.
patent: 5091652 (1992-02-01), Mathies et al.
patent: 5141609 (1992-08-01), Sweedler et al.
patent: 5173748 (1992-12-01), Bilhorn
patent: 5192412 (1993-03-01), Kambara et al.
patent: 5268080 (1993-12-01), Kambara et al.
patent: 5277780 (1994-01-01), Kambara
patent: 5314602 (1994-05-01), Kambara et al.
patent: 5366608 (1994-11-01), Kambara
patent: 5439578 (1995-08-01), Dovichi et al.
patent: 5470710 (1995-11-01), Weiss et al.
patent: 5529679 (1996-06-01), Takahashi et al.
patent: 5582705 (1996-12-01), Yeung et al.
patent: 5627643 (1997-05-01), Birnbaum et al.
patent: 5636017 (1997-06-01), Bruno et al.
patent: 5667656 (1997-09-01), Kambara
patent: 5675155 (1997-10-01), Pentoney et al.
patent: 5695626 (1997-12-01), Yeung et al.
patent: 5710628 (1998-01-01), Waterhouse et al.
patent: 5717602 (1998-02-01), Kenning
patent: 5730850 (1998-03-01), Kambara et al.
patent: 5741411 (1998-04-01), Yeung et al.
patent: 5741412 (1998-04-01), Dovichi et al.
patent: 5754291 (1998-05-01), Kain
patent: 5784157 (1998-07-01), Gorfinkel et al.
patent: 5790727 (1998-08-01), Dhadwal et al.
patent: 5833826 (1998-11-01), Nordman
patent: 5833827 (1998-11-01), Anazawa et al.
patent: 6005663 (1999-12-01), Waterhouse et al.
patent: 6017434 (2000-01-01), Simpson et al.
patent: 6084667 (2000-07-01), Melman et al.
patent: 6110683 (2000-08-01), Reynolds et al.
patent: 6140048 (2000-10-01), Müller et al.
patent: 6249341 (2001-06-01), Basiji et al.
patent: 6404495 (2002-06-01), Melman et al.
patent: 6529275 (2003-03-01), Amirkhanian et al.
patent: 0 616 211 (1994-09-01), None
patent: WO 9511961 (1995-05-01), None
patent: WO 9523348 (1995-08-01), None
patent: WO 9719342 (1997-05-01), None
patent: WO 9812536 (1998-03-01), None
Richard T. Reel,Camera Lens Spectrograph Optics Design for MegaGUT,pp. 1-42, (Jan. 16, 1997).
Milos V. Novotny,Capillary electrophoresis, Current Opinion in Biotechnology,vol. 7, pp. 29-34 (1996).
Simpson, et al.,A transmission imaging spectrograph and microfabricated channel system for DNA analysis, Electrophoresis 2000,vol. 21, pp. 135-149 (2000).
Ross, et al.,High Sensitivity is Key to CE Detection Boost, Today's Chemist at Work,Vo. 6(8), pp. 31-32, 34 and 36, (Sep. 1997).
Kostichka, et al.,High Speed Automated DNA Sequencing in Ultrathin Slab Gels, Bio/Technology,vol. 10, pp. 78-81, (Jan. 1992).
Karger, et al.,Multiwavelength fluorescence detection for DNA sequencing using capillary electrophoresis, Nucleic Acids Research,vol. 19, No. 18, pp. 4955-4962, (Jul. 29, 1991).
Genome Sequencing Center, Washington University School of Medicine St. Louis, MO USA,EST&GSS Projects,http://genome.wustl.edu/est/est_general/trace_intro.html., (Monday, Mar. 26, 2001).
Kevin Altria,Capillary electrophoresis, Royal Society of Chemistry,7 Sheets, (2000).
Paul D. Grossman,Factors Affecting the Performance of Capillary Electrophoresis Separations: Joule Heating, Electroosmosis, and Zone Dispersion, Academic Press, Inc.,pp. 3, 24, 28, and 38, (1992).
New Mexico Institute of Mining and Technology, Sorocco, NM USA,How the DNA sequencer works,http://www.nmt.edu/˜biology/sequencer.htm (no date).
Brochure,Charge-Coupled Devices for Quantitative Electronic Imaging, Photometrics, Ltd,pp. 1-3, and 6-17, (1992).
Sweedler, et al.,Fluorescence Detection in Capillary Zone Electrophoresis Using a Charge-Coupled Device with Time-Delayed Integration, Analytical Chemistry,vol. 63, No. 5, pp. 496-502, (Mar. 1, 1991).
F. Sanger, et al.,DNA Sequencing with Chain Terminating Inhibitors,74Proc. Nat. Acad. Sci. USA,5463, (1977).
Lloyd M. Smith, et al.,Fluorescence detection in automated DNA sequence analysis,321Nature674, (1986).
Lloyd M. Smith, et al.,The Future of DNA sequencing,262Science530, (1993).
L. Kricka,Nonisotopic DNA Probe Techniques, Academic Press,San Diego, pp. 3-28, (1992).
Bronstein,Anal. Biochemistry,219:169-81 (1993).
Charge-Coupled Devices for Quantitative Electronic Imaging,Photometrics Ltd., (1992).

Affiliated with

Also associated with

Rating

Time-delay integration in electrophoretic detection systems does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Time-delay integration in electrophoretic detection systems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Time-delay integration in electrophoretic detection systems will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3493308