Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1984-04-20
1986-07-22
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
A01N 4500, A61K 31705
Patent
active
046020055
ABSTRACT:
This invention discloses novel glycosides which are potent inhibitors of cholesterol absorption and therefore useful in treating hypercholesterolemia and atherosclerosis. Particularly useful in this respect is glycoside tigogenin cellobioside. The method of use for treatment of hypercholesterolemia and atherosclerosis, and the suitable pharmaceutical compositions are also disclosed.
REFERENCES:
patent: 4260603 (1981-04-01), Pegel et al.
Kintya et al, "Search for Hypocholesteremic Agents Among a Group of Steroid Glycosides", Kim.-Farm, Zh. (Sep. 1981) 15:9, pp. 56-60 (Russian, Eng. trans. enclosed).
Lasur'evskii, et al., "Steroid Glycosidases from Asparagus officinais L.,-Doklady ANSSR (reports of the USSR Academy of Sciences), (1976), vol. 1, No. 6, pp. 1479-1481.
Perepelitsa et al., "A Chemical Study of the Steroid Glycosides of Tribulus Terrestris-IV. Steoid Saponins", Khimiya Priorodnykh Soedinenii, 260-261 (1975).
Schelocochkova et al, "Diosgenin and Neotigogenin Gluocosides", Khimiya Priorodnykh Soedinenii, 1:103-104 (1979).
Lazur'evskii et al, "Structure of Steroid Glycosides of Leaves of Funkia ovata Spr.", Doklady Akadamii Nauk SSSR, vol. 230, pp. 476-477 (1976).
Lazur'evskii et al, "Steroid Glycosides from Leaves of Agava americana L." Doklady Akademie Nauk SSSR, 224:1422-1444 (1975).
Kintya et al, "Rockogenin Glycosides", Khimiya Priorodnykh Soedinenii, 1L102-103 (1979).
Buckles Ellen J.
Krubiner Alan M.
Medical Research Foundation of Oregon
Moran Tom M.
Roberts Elbert L.
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