Tie ligand-3, methods of making and uses thereof

Details Tie ligand-3, methods of making and uses thereof Tie ligand-3, methods of making and uses thereof

1996-06-19

1998-12-22

Spector, Lorraine M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

536 235, 530350, 530402, 4353201, 435325, 435348, 4352523, 43525411, 424 169, 4241781, C07K 14475, C12N 510, C12N 512, C12N 1564

Patent

active

058517979

ABSTRACT:
The present invention provides for an isolated nucleic acid molecule encoding TIE ligand-3. In addition, the invention provides for a receptorbody which specifically binds TIE ligand-3. The invention also provides an antibody which specifically binds TIE ligand-3. The invention further provides for an antagonist of TIE. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE receptor, a method of blocking the growth or differentiation of a cell expressing the TIE receptor and a method of attenuating or preventing tumor growth in a human.

REFERENCES:
patent: 5447860 (1995-09-01), Ziegler
patent: 5521073 (1996-05-01), Davis et al.
patent: 5643755 (1997-07-01), Davis et al.
patent: 5650490 (1997-07-01), Davis et al.
Oncogene, vol. 9, No. 11, issued Nov. 1994, Fletcher et al "LERK-2, a binding protein for the receptor-tyrosine kinase ELK, is evolutionarily conserved and expressed in a developmentally regulated pattern", pp. 3241-3247.
Oncogene, vol. 10, No. 2, issued Jan. 1995, Kozlosky et al., "Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins", pp. 299-306.
Oncogene, vol. 8, No. 6, Jun. 1993, P.C. Maisonpierre, et al., "Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family", pp. 1631-1637.
The Embo Journal, vol. 13, No. 16, issued 1994, Beckmann et al., "Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors", pp. 3757-3762.
Nature, vol. 368, issued Apr. 7, 1994, Bartley et al., "B61 is a ligand for the ECK receptor protein-tyrosine kinase", pp. 558-560.
Nature, vol. 347, issued Oct. 25, 1990, Cattaneo et al., "Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor", pp. 762-765.
Biochemistry, vol. 29, 1990, Derynck, et al., "Recombinant Expression, Biochemical Characterization, and Biological Activities of the Human MGSA/gro Protein" pp. 10225-10233.
Proc. Natl. Acad. Sci. USA, vol. 77, No. 12, 1980, Weissenbach, et al., Two interferon mRNAs in human fibroblasts: In vitro translation and Escherichia coli cloning studies, pp. 7152-7156.
Proc. Natl. Acad. Sci. USA, vol. 87, 1990, Partanen, et al., "Putative tyrosine kinases expressed in K-562 human leukemia cells", pp. 8913-8917.
Molecular and Cellular Biology, vol. 12, No. 4,, 1992, Partanen, et al., "A Novel Endothelial Cell Surface Receptor Tyrosine Kinase with Extracellular Epidermal Growth Factor Homology Domains", pp. 1698-1707.
Sato et al., Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessels formation, Nature, 376(6535): 70-74, Jul. 6, 1995.
Sato et al., tie-1 and tie-2 define antoher class of putative recepotr tyrosine kinase genes expressed in early embryonic vascular system, Proc. Natl. Acad. Sci. USA, 90:9355-9358, Oct. 1993.
Dumont et al., Dominant-negative and targeted null mutations in the endothelial recptor tyrosine kinase, tek, reveal, a critical role in vasculogenesis of the embryo, Genes Dev., 8:1897-1909, Aug. 1994.

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