Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-10-27
1996-05-28
Draper, Garnette D.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 701, 4352402, 4352523, 4353201, 935 22, 935 69, 935 70, 935 72, 536 231, 536 235, 536 243, 536 2431, C12N 1512, C07K 1300
Patent
active
055210732
ABSTRACT:
The present invention provides for an isolated nucleic acid molecule encoding human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds human TIE-2 ligand. The invention also provides an antibody which specifically binds human TIE-2 ligand. The invention further provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization and a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor.
REFERENCES:
Weissenbach et al. (1980) Proc. Natl. Acad. Sci. vol. 77, No. 12, pp. 7152-7156.
Derynck et al. (1990) Biochemistry, vol. 29, pp. 10225-10233.
Aldrich Thomas H.
Davis Samuel
Yancopoulos George D.
Cobert Robert J.
Draper Garnette D.
Mertz Prema
Regeneron Pharmaceuticals Inc.
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