Tie-2 ligand 1

Details Tie-2 ligand 1 Tie-2 ligand 1

1994-12-02

1999-03-09

Ulm, John

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 514 2, 514 8, 514 12, 435 695, 4352523, 4353201, 435325, A61K 3819, C07K 1452

Patent

active

058796720

ABSTRACT:
The present invention provides for an isolated nucleic acid molecule encoding human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds human TIE-2 ligand. The invention also provides an antibody which specifically binds human TIE-2 ligand. The invention further provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization and a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor.

REFERENCES:
Pataneu et al. (1990), Proc. Natl. Acad. Sci. vol. 87, pp. 8913-8917.
Partaneu et. al. (1992), Mol. & Cell. Biol. vol. 12, No. 4, pp. 1698-1707.

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