Thyroxine-and triiodothyronine-tyrosine dipeptide derivatives

Details Thyroxine-and triiodothyronine-tyrosine dipeptide derivatives Thyroxine-and triiodothyronine-tyrosine dipeptide derivatives

1975-03-19

1976-09-28

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 15, 260559A, C07G10352, C07G 700

Patent

active

039830993

ABSTRACT:
The present invention is concerned with the production of novel derivatives of thyroid hormones which are useful in the radioimmunoassay (RIA) of such hormones. The invention is particularly concerned with derivatives of thyroxine and triiodothyronine which contain an additional phenol group which is readily iodinatable so that the phenol conjugate can be readily tagged with a radioactive iodine isotope, such as .sup.125 I or .sup.131 I, without detrimentally interfering with the ability of the tagged conjugate so competitively bind with the naturally occurring thyroid hormone in the biological liquid to be analyzed by RIA technique. The invention is also concerned with the iodine-tagged derivatives or conjugates.

REFERENCES:
patent: 3715434 (1973-02-01), Mende

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