Thyroxine analogs and reagents for thyroid hormone assays

Details Thyroxine analogs and reagents for thyroid hormone assays Thyroxine analogs and reagents for thyroid hormone assays

1986-07-08

1988-05-03

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

435 7, 436500, 548335, 548342, 548344, 560 12, 560 17, 560 35, 560 40, 562426, 562430, 562440, 562447, 564 74, 564157, 564174, 564276, 568 33, G01N 3353

Patent

active

047418974

ABSTRACT:
The present invention relates to new compounds of the general formula: ##STR1## where X is iodine or hydrogen; A is a linking portion; and R is an iodinatable aryl or heteroaryl group having electron donating substituents. These compounds are useful precursors to the iodinated thyroid hormones for radioimmunoassay determination of thyroid hormones in biological fluids.

REFERENCES:
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patent: 4225574 (1980-09-01), Romelli et al.
patent: 4489165 (1984-12-01), Wagner et al.
J. Stokigt, et al., Clinical Endocrinology, 15, 313-318 (1981).
J. Stokigt, et al., Clinical Chemistry 29, 1408-1410 (1983).
J. Midgley, et al., Clinical Endocrinology, 7, 523-528 (1982).
M. Bayer, Clinica Chimica Acta, 130, 391-396 (1983).
N. Amino, et al., Clinical Chemistry, 29, 321-325 (1983).
T. Andrea, et al., Biochemistry, 19, 55-63 (1980).
W. Wiersinga, et al., in Methods in Enzymology, vol. 84, J. Langone, et al., (editors), Academic Press, New York, 1982, pp. 272-302.

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