Thyroxin-binding HSA fragments

Details Thyroxin-binding HSA fragments Thyroxin-binding HSA fragments

1994-03-21

1997-12-16

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530363, A61K 3838, C07K 14765

Patent

active

056985177

ABSTRACT:
Modified forms of human serum albumin (HSA) wherein the arginine at position 218 is substituted by a less basic amino acid show strong thyroxin-binding activity. These modified forms of HSA and fragments thereof are useful in binding thyroxin in standard assays for free thyroxin concentration and in treating conditions characterized by higher-than-desired levels of free thyroxin in animal subjects.

REFERENCES:
patent: 5380712 (1995-01-01), Ballance et al.
Dughie, "Fluorescence Investigations of Albumin From Patients With Familial Dysalbuminemic Hyperthyroxinemia", Photochem. Photobiol., 57:416-19 (1993).
Takamatsu et al. "Diagnosis of familial dysalbuminemic hyperthyroxinemia and investigation of the nature of the variant albumin" Bull. Osaka Med. Coll. 36(1,2):35-45, 1990.
Yabu, Y. et al. (1985) "Heterogeneity of thyroxine binding by serum albumins in normal subjects and patients with FDH" J. Clin. Endocrinol. Metab 60(3):451-9.
Lalloz, M.R.A. et al. (1983) "Hyperthyroxiaemia: abnormal binding of T4 by an inherited albumin variant" Clin. Endocrinol. 18:11-24.

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