Thyronamine derivatives and analogs and methods of use thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S654000

Reexamination Certificate

active

06979750

ABSTRACT:
Thyronamine derivatives and analogs, methods of using such compounds, and pharmaceutical compositions containing them are disclosed. Methods of preparing such compounds are also disclosed.

REFERENCES:
Database CAPLUS on STN, Acc. No. 1971:135556, Fuller et al., J. of Medicinal Chemistry (1971), 14(4), p. 322-325 (abstract.
Yen, P.M., “Physiological and Molecular Basis of Thyroid Hormone Action”,Physiol. Rev.81: 1097-1142, 2001.
Falkenstein, E., et al., “Multiple Actions of Steroid Hormones-A Focus on Rapid, Nongenomic Effects”,Pharmacol. Rev.52: 513-555, 2000.
Walker, J.D., et al., “The novel effects of 3,5,3'-triiodo-L-thyronine on myocyte contractile function and β-adrenergic responsivness in dilated cardiomyopathy”,J. Thorac. Cardiovasc. Surg.108: 672-679, 1994.
Sun, Z.-Q., et al., “Effects of thyroid hormone on action potential and repolarizing currents in rat ventricular myocytes”,Am. J. Physiol. Endocrinol. Metab.278: E302-E307, 2000.
Hamilton, M.A., et al., “Safety and Hemodynamic Effects of Intravenous Triiodothyronine in Advanced Congestive Heart Failure”,Am. J. Cardiol.81: 443-447, 1998.
Buu-Hoi, N.P., et al., “Thyronamine, a New Substance with Long-acting positive Inotropic Effect”,Pharmacology2: 281-287, 1969.
Boissier, J.R., et al., “Differential Inotropic-Chronotropic Action of Thyronamine”,Eur. J. Pharmacol.22: 141-149, 1973.
Cote, P., et al., “Thyronamine, a new inotropic agent: its cardiovascular effects and mechanism of action”,Cardiovascular Res.8: 721-730, 1974.
Dratman, M., “On the Mechanism if Action of Thyroxin, an Amino Acid Analog of Tyrosine”,J. theor. Biol., 46: 255-270, 1974.
Han, et al., “Synthesis of side chain-modified idothyronines”,Int. J. Peptide Protien Res., 30: 652-661, 1987.
Rozanov, C.B., et al., “Immunohistochemical Mapping of Brain Triiodothyronine Reveals Prominent Localization in Central Noradrenergic Systems”,Neuroscience, 74: 897-915, 1996.
Tomita, K., et al., “Synthesis and Biological Activity of Some Triiodinated Analogues of Thyroxine”,J. Biol. Chem.219: 595-604, 1956.
Biondi, B., et al., “Effects of Subclinical Thyroid Dysfunction on the Heart”,Ann Intern Med., 137: 904-914, 2002.
Thibault, O., “Recherhes sur la nature de la <<thyroxine active>> . Renforcement immediate par la thyroxamine des effets de I'adrénaline sur divers muscles lisses”, 1951C.R. Soc. Chim. biol., 797-800.
Meyer, T., et al., “Triiodothyronamine- A Beta-adrenergic Metabolite of Triiodothyronine?”,Horm. metabol. Res.15: 602-606, 1983.
Buu Hoi; N.P. et al., “Some Biological Effects of Thyronamine”,Med. Pharmacol. exp.15:17-23, 1966.
Bunzow, J.R., et al., “Amphetamine, 3,4-Methylenedioxymethamphetamine, Lysergic Acid Diethylamide, and Metabolites of the Catecholamine Neurotransmitters are Agonists of a Rat Trace Amine Receptor”,Mol. Pharmacol.60: 1181-1188, 2001.
Borowsky, B., et al., “Trace amines: Identification of a family of mammalian G protein-coupled receptors”,Proc. Natl. Acad. Sci.98: 8966-8971, 2001.
Stöhr, R., “Synthese des Thyronamins”,Hoppe-Seyler Z. physiol. Chem.201: 142-149, 1931.
Petit, L. et al., “A Synthesis of Thyronamine and its Lower Homolog”,J. org. Chem.26: 3832-4, 1961.
Cody et al., “Molecular Structure and Biochemical Activity of 3,5,3'-Triiodothyronamine”,Endocrine Research, 10: 91-99, 1984.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Thyronamine derivatives and analogs and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thyronamine derivatives and analogs and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thyronamine derivatives and analogs and methods of use thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3505935

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.