Thyroid sodium/iodide symporter and nucleic acid encoding same

Details Thyroid sodium/iodide symporter and nucleic acid encoding same Thyroid sodium/iodide symporter and nucleic acid encoding same

2008-01-22

2008-01-22

Strzelecka, Teresa E. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S023100, C536S024300, C536S024310, C536S024330

Reexamination Certificate

active

07320863

ABSTRACT:
The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed with the vector, and a method for producing recombinant sodium/iodide symporter. In addition, the present invention provides nucleic acid probes and mixtures thereof specific for sodium/iodide symporter nucleic acid and antibodies immunoreactive with sodium/iodide symporter. The present invention also provides a method for diagnosing and treating thyroid disorders associated with non-functional sodium/iodide symporter. Furthermore, the present invention provides a method for the selective ablation of tissue. The present invention also provides a method for identifying an iodide transport protein in non-thyroid tissue. Finally, the present invention provides a non-human, transgenic model for a thyroid disorder.

REFERENCES:
patent: 5442049 (1995-08-01), Anderson et al.
patent: 5474796 (1995-12-01), Brennan
patent: 6391579 (2002-05-01), Carrasco et al.
patent: 6803199 (2004-10-01), Carrasco et al.
patent: WO 92/13102 (1992-08-01), None
GenBank Accession No. L14901Petromyzon marinus(clone Pm57-q) homeobox gene, partial cds (1993).
Kessler, C., J. Biotechnol., vol. 35, pp. 165-189 (1994).
Maniatis et al (1982) Molecular Cloning A Laboratory Manual. Cold Spring Harbor Laboratory.
Hediger, MA et al. (1987) Expression cloning and cDNA sequencing of the Na+/glucose co-transporter. Nature, vol. 330, pp. 379-381.
Guastella, J et al. Cloning and Expression of a Rat Brain GABA Transporter. (1990) Science, vol. 249, pp. 1303-1306.
Russell et al. “Protein, 618 AA”; Database: A—Geneseq—0601: Accession No. AAB73921: May 29, 2001.
Vilijn, F et al. “Expression of the Thyroid Sodium/Iodide Symporter inXenopus laevisOocytes,” The Journal of Biological Chemistry, vol. 264, No. 20, Jul. 15, 1989, pp. 11901-11903.
Bonaldo, MR et al., “Normalization and subtraction: two approaches to facilitate gene discovery,” Genome Research, 1996, vol. 6, pp. 791-806.
Kaminsky S M, et al., entitled “Na+-I-symport activity is present in membrane vesicles from thyrotropin-deprived non-I-transporting cultured thyroid cells,” Proceedings of the National Academy of Sciences of the United States, vol. 91, No. 9, 1994 pp. 3789-3793.
Dai G et al., entitled “Rattus norvegicusthyroid sodium/iodide symporter NIS mRNA, complete cds,” Database NCBI Online, GenBank; U60282. 2 pages. Jul. 2, 1996.
Dai G et al., entitled “Na/I symporter,” Database NCBI Online, 2204393A. 1 page. Oct. 30, 1996.
Dai G et al., entiteld “Cloning and Characterization of the Thyroid Iodide Transporter,” Nature, vol. 379, Feb. 1, 1996, pp. 458-460.
Smanik P A et al., entitled “Cloning of the Human Sodium Iodide Symporter,” Biochemical and Biophysical Research Communications, vol. 226, No. 2, Sep. 13, 1996, pp. 339-345.
Hediger M A et al., entitled “Homology of the human intestinal Na+/glucose andEscherichia coliNa+/proline contransporters,” PNAS, vol. 86, Aug. 1989, pp. 5748-5752.
Uni Prot Database: Primary Accession No. P26430: Entry name: SC5A2—RABIT; “Na(+)
ucleoside contransporter,” 3 pages, Aug. 1, 1992.
Carrasco N, entitled “Iodide transport in the thyroid gland,” Biochimica et Biophysica Acta, 1993, vol. 1154, pp. 65-82.
Shimoda N et al., entitled “Mermaid: A family of short interspersed repetitive elements widespread in vertebrates,” Biochemical and Biophysical Research Communications, 1996, vol. 220, p. 226-232.

Affiliated with

Also associated with

Rating

Thyroid sodium/iodide symporter and nucleic acid encoding same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Thyroid sodium/iodide symporter and nucleic acid encoding same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thyroid sodium/iodide symporter and nucleic acid encoding same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2774176