Thyroid hormone receptor ligand, medicinal compositions...

Details Thyroid hormone receptor ligand, medicinal compositions... Thyroid hormone receptor ligand, medicinal compositions...

2007-06-12

2007-06-12

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C560S012000

Reexamination Certificate

active

10502737

ABSTRACT:
The present invention provides a compound represented by general formula (I):or pharmaceutically acceptable salts thereof, wherein W is O, S(O)m, CH2and the like; R1is halogen, lower alkyl, halo-lower alkyl, CN and the like; R3is hydrogen and the like; R4is hydrogen, halogen, alkyl, halo-lower alkyl, substituted alkyl, aryl, aralkyl, alkoxy, substituted alkoxy, alkanoyl, aroyl, —CONR7(R8), —S(O)mR9, —SO2NR7(R8) and the like; R5is hydrogen, halogen, alkyl, substituted alkyl and the like; A is —N(R6)CO—A1—COR10and the like; pharmaceutical compositions containing them and their uses, which have a high affinity to human thyroid hormone receptors, in particular human thyroid hormone receptor β.

REFERENCES:
patent: 6545018 (2003-04-01), Chiang et al.
patent: 1 033 364 (2000-09-01), None
patent: WO 00/07972 (2000-02-01), None
patent: WO 00/39077 (2000-07-01), None
patent: WO 00/51971 (2000-09-01), None
Schroeder et al. (Eur. Journ. Med. Chem., vol. 17, Issue 1, pp. 35-42).

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