Thyroid hormone receptor antagonists for cardiac and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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Details

C514S366000, C514S374000, C514S576000, C514S617000, C548S203000, C548S247000, C562S108000, C562S465000, C562S621000

Reexamination Certificate

active

07319096

ABSTRACT:
This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosis, subclinical hyperthyrodism and liver diseases.

REFERENCES:
patent: 99/00353 (1999-01-01), None
patent: 00/07972 (2000-02-01), None
patent: 01/36365 (2001-05-01), None
Silverman, Richard, The Organic Chemistry of Drug Design and Drug Action, 1992, Academic Press, Inc, p. 19-23.
Gonzalez-Sancho et al, Thyroid hormone receptors/THR gene in human cancer, 2003, 192, Cancer Letters, p. 121-132.
Forrest, Douglas, The Thyroid Hormone Receptor Family: Insights from Knockouts, Sep. 2002, 3, Hot Thyroidology, p. 1-4.
Chiellini, G. et al. “A High-Affinity Subtype-Selective Agonist for the Thyroid Hormone Receptor,”Chemistry and Biology, vol. 5, No. 6, pp. 299-306 (1998).
L. M. Lima and E. J. Barreio, “Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design”, Current Medical Chemistry, vol. 12, No. 1, pp. 23-49 (2005).
George A. Patani and Edmond J. Lavoie, “Bioisosterism: A Rational Approach in Drug Design,” Chemical Reviews, vol. 96, No. 8, pp. 3147-3176 (Jul. 25, 1996).

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