Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-11-12
1994-12-20
Russel, Jeffrey E.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
43524031, 623 13, A61F 208, C12N 508
Patent
active
053745507
ABSTRACT:
Thyroid-derived chondrocyte stimulating factor (TDCSF) is a high molecular weight complex (greater than 500 kd) of proteinaceous subunits which can be at least partially dissociated into active portions by 8M urea. TDCSF stimulates articular chondrocyte and synovial fibroblast growth under serum-free conditions. TDCSF is useful for the culture of chondrocytes and fibroblasts in vitro as a serum substitute; for developing cartilage implants in vitro; and for in vivo use in cartilage and bone defect repair and degenerative joint diseases. TDCSF is stabilized in the presence of reducing agents for disulfide bonds. Antibodies for and conjugates of TDCSF are also disclosed.
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Jones Deryk G.
Smith R. Lane
Russel Jeffrey E.
The Board of Trustees of the Leland Stanford Junior University
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