Thyroid-derived chondrocyte-stimulating factor

Details Thyroid-derived chondrocyte-stimulating factor Thyroid-derived chondrocyte-stimulating factor

1991-02-13

1994-02-08

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530399, 530854, A61K 3736, C07K 302, C07K 1506

Patent

active

052848302

ABSTRACT:
Thyroid-derived chondrocyte stimulating factor (TDCSF) is a high molecular weight complex (greater than 500 kd) of proteinaceous subunits which can be at least partially dissociated into active portions by 8 M urea. TDCSF stimulates articular chondrocyte and synovial fibroblast growth under serum-free conditions. TDCSF is useful for the culture of chondrocytes and fibroblasts in vitro as a serum substitute; for developing cartilage implants in vitro; and for in vivo use in cartilage and bone defect repair and degenerative joint diseases. TDCSF is stabilized in the presence of reducing agents for disulfide bonds. Antibodies for and conjugates of TDCSF are also disclosed.

REFERENCES:
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Jones et al., Clin. Res. vol. 37 No. 1, Meeting Abstract 224A (Jan. 1989)
Biosis Abstract 67034672, Madelmnd et al., Connect Tiss. Res. vol. 6(1) 1978 pp. 1-10.

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