Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Reexamination Certificate
2007-12-06
2011-10-04
Menon, Krishnan S (Department: 1777)
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
C435S004000, C435S007100, C435S007800, C436S171000, C436S173000
Reexamination Certificate
active
08030084
ABSTRACT:
Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.
REFERENCES:
patent: 6107623 (2000-08-01), Bateman et al.
patent: 6124137 (2000-09-01), Hutchens et al.
patent: 6204500 (2001-03-01), Whitehouse et al.
patent: 6268144 (2001-07-01), Koster
patent: 2004/0072251 (2004-04-01), Anderson
patent: 2005/0064422 (2005-03-01), Barnidge et al.
patent: 2006/0223188 (2006-10-01), Soldin
patent: 2007/0105179 (2007-05-01), Madson
patent: 2007/0224628 (2007-09-01), Gordon et al.
patent: 2009/0042213 (2009-02-01), Hoofnagle et al.
patent: WO/2008/027861 (2008-03-01), None
Bartolucci et al., Liquid chromatography tandem mass spectrometric quantitation of sulfamethazine and its metabolites: direct analysis of swine urine by triple quadrupole and by ion trap mass spectrometry. Rapid Communications in Mass Spectrometry, 14: 967-973, 2000.
Bourrel et al. , Immunoradiometric Assay of Thyroglobulin in Patients with Differentiated Thyroid Carcinomas: Need for Thyroglobulin Recovery Tests, Clin. Chem. Lab Med 36(8): 725-730 (1998).
Di Jeso, et al., Mixed-Disulfide Folding Intermediates between Thyroglobulin and Endoplasmic Reticulum Resident Oxidoreductases ERp57 and protein Disulfide Isomerase, Molecular and Cellular Biology 25(22): 9793-9805 (2005).
Dunn et al., Tyrosine 130 is an Important Outer Ring Donor for Thyroxine Formation in Thyroglobulin, J. Biol. Chem. 273(39):25223-25229 (1998).
Dunn et al., The Sites of Thyroid Hormone Formation in Rabbit Thyroglobulin, The Journal of Biological Chemistry 262(35):16948-16952 (1987).
Kim et al., Folding and Assembly of Newly Synthesized Thyroblobulin Occurs in a Pre-Golgi Compartment, The Journal of Biological Chemistry 266(19): 12412-12418 (1991).
Merchant, M. and S. R. Weinberger, Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry, Electrophoresis, 21:1164-67, (2000).
Persoon et al., Clinical Utility of an Automated Immunochemiluminometric Thyroglobulin Assay in Differentiated Thyroid Carcinoma, Clinical Chem. 52(4):686-691 (2006).
Persoon et al., Thyroblobulin (Tg) Recovery Testing with Quantitative Tg Antibody Measurement for Determining Interference in Serum Tg Assays in Diffferentiated Thyroid Carcinoma, Clinical Chem. 52(6): 1196-1199 (2006).
Robb et al., Atmospheric pressure photoionization: An ionization method for liquid chromatography-mass spectrometry. Anal. Chem. 72(15): 3653-3659.
Salek et al., Analysis of thyroblobulin iodination by tandem mass spectrometry using immonium ions of monoiodo- and diiodo-tyrosine, Proteomics, 5(2):351-353 (2005).
Salm et al., The Quantification of Sirolimus by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Microparticle Enzyme Immunoassay in Renal Transplant Recipients, Clin. Therapeutics 22 Supl. B:B71-B85, (2000).
Spencer et al., Thyroglobulin Measurement Techniques, Clinical Benefits, and Pitfalls, Endocrinol Metab Clin North Am. 24(4):841-863 (1995).
Spencer et al., Detection of Residual and Recurrent Differentiated Thyroid Carcinoma by Serum Thyroglobulin Measurement, Thyroid, 9(5):435-41 (1999).
Taylor et al., Simultaneous Quantification of Tacrolimus and Sirolimus, in Human Blood, by High-Performance Liquid Chromatography-Tandem Mass Spectrometry, Therapeutic Drug Monitoring 22:608-12, (2000).
Wright et al., Proteinchip® surface enhanced laser desorption/ionization (SELDI) mass spectrometry: a novel protein biochip technology for detection of prostate cancer biomarkers in complex protein mixtures, Prostate Cancer and Prostatic Diseases 2:264-76, (1999).
International Search Report for PCT Application No. PCT/US08/85435.
International Preliminary Report on Patentability dated Jun. 8, 2010.
Clarke Nigel J.
Reitz Richard E.
Zhang Yanni
Foley & Lardner LLP
Fritchman Rebecca
Menon Krishnan S
Quest Diagnostics Investments Incorporated
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