Thymus tolerance in primates

Details Thymus tolerance in primates Thymus tolerance in primates

1997-04-11

1998-06-09

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

4241541, 4241831, 424534, 5303911, 5303917, 5303919, A61K 39395, A61K 3512, C07K 1628

Patent

active

057629277

ABSTRACT:
Disclosed is a method of inhibiting a rejection response by a primate to a transplanted organ. One exposes the primate to a mutant diphtheria toxin linked to anti-CD3 antibody so as to largely eliminate the host's peripheral blood T cell lymphocyte population. At the same time as, or after, the exposure step one administers to the primate's thymus gland donor lymphocytes. Transplantation of the organ follows. The primate is tolerized to the transplanted organ.

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