Thymus-specific protein

Details Thymus-specific protein Thymus-specific protein

2005-10-26

2011-12-06

Gamett, Daniel C (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S326000, C530S324000, C514S001100

Reexamination Certificate

active

08071716

ABSTRACT:
The invention provides the novel thymus-specific human protein T101, an 84-amino acid polypeptide isolated from the human thymus. The full T101 peptide contains a 33-amino acid signal peptide and a 51-amino acid T101 peptide sequence with both immune stimulatory and inhibitory activities. Also provided are modified peptides and partial T101 peptide sequences.

REFERENCES:
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patent: 01/77137 (2001-10-01), None
patent: 2004/005318 (2004-01-01), None
Harris, et al. (1994).Three distinct human thymopoietins are derived from alternatively spliced mRNAs. Proceedings of the National Academy of Sciences of the United States of America, vol. 91, No. 14, 1994, pp. 6283-6287, XP-002379435.
DATABASE UniProt, Aug. 1, 1998, “Integral membrane acetyltransferase.” XP-002379438, retrieved from EBI accession No. UANIPROT:066257.
DATABASE EMBL, Dec. 14, 1999, “Human DNA sequence from clone RP11-481H12 on chromosome 10 Contains a FK506 binding protein 1B (FKBP1B) pseudogene.” XP-002379439, retrieved from EBI accession No. EM PRO:AL133482.
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Periti, et al. (1993). Antimicrobial chemoimmunoprophylaxis in Colorectal Surgery with Cefotetan and thymostimulin: prospective, controlled multicenter study. Journal of Chemotherapy. vol. 5,1, pp. 37-42.

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