Thymosin β4 compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C514S012200, C514S002600, C530S399000, C930S180000

Reexamination Certificate

active

10853505

ABSTRACT:
A composition with a polypeptide including amino acid sequence LKKTET [SEQ ID NO:1] or a conservative variant thereof, the composition further including a carrier for application to a surface of a body.

REFERENCES:
patent: 4389343 (1983-06-01), Horecker
patent: 4543340 (1985-09-01), Goldstein et al.
patent: 5578570 (1996-11-01), Goldstein et al.
patent: 5663071 (1997-09-01), Zetter et al.
patent: 6030948 (2000-02-01), Mann
patent: 6602519 (2003-08-01), Stevenson et al.
patent: 0 124 779 (1984-11-01), None
patent: 0 450 240 (1991-10-01), None
patent: 1 100 529 (2001-05-01), None
patent: WO94/11499 (1994-05-01), None
patent: WO94/18988 (1994-09-01), None
patent: WO94/23739 (1994-10-01), None
patent: WO95/09646 (1995-04-01), None
patent: WO96/16983 (1996-06-01), None
patent: WO97/48805 (1997-12-01), None
patent: WO99/49883 (1999-10-01), None
Malinda et al., FASEB Journal, vol. 11, No. 6, May 1997, pp. 474-481.
Malinda, K.M., et al., “Thymosin B4 stimulates directional migrational of human umbilical vein endothelial cells,” FASEB Journal, vol. 11, No. 6 (1997), pp. 474, 481.
Sun, H-Q, et al., “B-Thymosins are not simple actin monomer buffering proteins. Insights from overexpression studies,” Journal of Biological Chemistry, vol. 271, No. 16 (1996), pp. 9223-9230.
Nimni, M.E., “Polypeptide growth factors: targeted delivery systems,” BIOMATERIALS, vol. 18, No. 18 (1997), pp. 1201-1225.
Frank, S., et al., “Regulation of vascular endothelial growth factor expression in cultured keratinocytes,” Journal of Biological Chemistry, vol. 270, No. 21 (1995), pp. 12607-12613.
Sabolinski, M.L. et al., “Cultured skin as a ‘smart material’ for healing wounds: experience in venous ulcers,” BIOMATERIALS, vol. 17, No. 3, (1996), pp. 311-320.
Hannappel, E., et al., “Actin-sequestering ability of thymosin B4, thymosin B4 fragments, and thymosin B4-like peptides as assessed by theDnase I inhibition assay,” Biol. Chem. vol. 374 (1993), pp. 117-122.
Jorneskog, K., et al., “Low molecular weight heparin seems to improve local capillary circulation and healing of chronic foot ulcers in diabetic patients,”VASA, pp. 137-142, (1993).
Kubler, M. Dominique, et al., “Changes in the distribution of actin-associated proteins during epidermal wound healing”,Journal of Investigative Dermatology, vol. 100, No. 6, (Jun. 1993), pp. 785-789.
Malinda, K.M., et al., “Thymosin β4 accelerates wound healing,”Journal of Investigative Dermatology, vol. 113, No. 6, pp. 364-368, (Sep. 1999).
Cavasin, M.A., et al., “Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP”,Hypertension, May 2004; pp. 1-6; vol. 43.
Peng, H., et al., “Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension”,Hypertension, 42; Dec. 2003; pp. 1164-1170.
Philp, D., et al., “Thymosin β4 and a synthetic peptide containing its actin-binding domain promote demal wound repair in db/db diabetic mice and in aged mice”,Wound Rep, and Regen, 11:1; 2003, pp. 19-24.
Philp, D., et al., “Thymosin β4 promotes angiogenesis, wound healing, and hair follicle development”,Mech Ageing Dev., 125:2; 2004; pp. 113-115 (Abstract only).
Philp, D., et al., “The actin binding site of thymosin β4 promotes angiogenesis”,The FASEB Jour., Sep. 18, 2003; 13 pages.
Philp, D., et al., “Thymosin β4 increases hair growth by activation of hair follicle stem cells”,The FASEB Jour., Dec. 4, 2003; 16 pages.
Simenel, C., et al., “Structural requirements for thymosin β4 in its contact with actin: An NMR-analysis of thymosin β4 mutants in solution and correlation with their biological activity”,Eur. J. Biochem., 267; 2000; pp. 3530-3538.
Yang, F, et al., “Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction”,Hypertension, 43; Feb. 2004; pp. 229-236.
Vancompernolle, K., et al., “G- to F-actin modulation by a single amino acid substitution in the actin binding site of actobindin and thymosin β4”,The EMBO Journal, 11:13; 1992; pp. 4739-4746.
Van Troys, M., et al., “The actin binding site of thymosin β4 mapped by mutational analysis”,The EMBO Journal, 15:2; 1996; pp. 201-210.

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