Thymosin beta 3 and beta 4

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424177, C07C10352, A61K 3700

Patent

active

042972760

ABSTRACT:
Two related polypeptides, thymosin .beta..sub.3 and thymosin .beta..sub.4, have been isolated from Thymosin fraction 5. These peptides have been characterized and sequenced. Thymosin .beta..sub.3 has 50 amino acid residues while thymosin .beta..sub.4 has 43 amino acid residues corresponding identically to the amino terminal 43 amino acids of thymosin .beta..sub.3. The compounds have useful biological activity as evidenced by their ability to induce terminal deoxynucleotidyl transferase (TdT) positive cells in T-cell populations. The invention described herein was made in part in the course of work under a grant or award from the Department of Health, Education and Welfare.

REFERENCES:
patent: 4079127 (1978-03-01), Goldstein et al.

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