Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-11-20
2007-11-20
Gupta, Anish (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S399000
Reexamination Certificate
active
10493690
ABSTRACT:
A pharmaceutical composition includes a physiologically active conjugate including a Thymosin alpha 1 (TA1) peptide conjugated to a material which increases half-life of the TA1 peptide in serum of a patient when the conjugate is administered to a patient. The material may be a substantially non-antigenic polymer. In a method of the invention, the substantially non-antigenic polymer is conjugated to a TA1 peptide. Compositions according to the invention are administered to patients in need of immune stimulation.
REFERENCES:
patent: 4079127 (1978-03-01), Goldstein et al.
patent: 4179337 (1979-12-01), Davis et al.
patent: 4353821 (1982-10-01), Birr et al.
patent: 4766106 (1988-08-01), Katre et al.
patent: 4917888 (1990-04-01), Katre et al.
patent: 5122614 (1992-06-01), Zalipsky
patent: 5595732 (1997-01-01), Hakini et al.
patent: 5632983 (1997-05-01), Hadden
patent: 6177074 (2001-01-01), Glue et al.
patent: 6309633 (2001-10-01), Ekwuribe et al.
patent: 2005/0114037 (2005-05-01), Desjarlais et al.
patent: 10654565 (1992-10-01), None
patent: WO 94/13314 (1994-06-01), None
patent: WO 95/13090 (1995-05-01), None
File Hcaplus on STN, DN No. 118:167075. Knusli et al. Polyethylene glycol (PEG) modification of granulocyte-macrophage colony stimulating factor (GM-CSF) enhances neutrophil priming activity but not colony stimulating activity. British Journal of Haematology (1992), 82(4), 654-63 (abstract only).
File Hcaplus on STN, DN No. 123:81299. Tsutsumi et al. Molecular design of hybrid tumor necrosis factor alpha with polyethylene glycol increases its anti-tumor potency. British Journal of Cancer (1995), 71(5), 963-8 (abstract only).
Chiu, H. et al., “Enzymatic activity of chymotrypsin and its poly(ethylene glycol) conjugates toward low and high molecular weight substrates,”,Bioconjugate Chem.1993, 4;290-295.
Schiavon, O., et al., “Therapeutic proteins: a comparison of chemical and biological properties of uricase conjugated to linear or branched poly(ethylene glycol) and poly(N-acryloylmorpholine)”,II Farmaco2000,55:264-269.
Rodrigues, P., et al., “Acid-sensitive polyethylene glycol conjugates of doxorubicin: preparation, in vitro efficacy and intracellular distribution”,Bioorg Med Chem.1999;7:2517-2524.
Nodake, Y., et al., “Some properties of a macromolecular conjugate of lysozyme prepared by modification with a monomethoxypolyethylene glycol derivative”,Biosci Biotechnol Biochem.2000;64:767-774.
Grace, M. et al., “Site of pegylation and polyethylene glycol molecule size attenuate interferon-alpha antiviral and antiproliferative activities through the JAK/STAT signaling pathway”,J. Biol Chem.2005;280:6327-6336.
Bailon, P. et al., “Rational design of a potent, long-lasting form of interferon: a 40 kDa branched polyethylene glycol-conjugated interferon alpha-2a for the treatment of hepatitis C”,Bioconjug Chem.2001;12:195-202 (1 page).
Wang, Y.S. et al., “Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications”,Adv Drug Deliv Rev.2002;54:547-570 (1 page).
Queensborough Community College: The City University of New York, The New York Chemistry Students'Association, Student Affiliate Committee—New York Section(American Chemical Society), May 1, 2004, 1-46, (Huang et al., p. 30).
Clinical application and foreground of Thymosin a1 in treating virus hepatitis, 2000, Section of Virology Foreign Medical Sciences (7)6:168-171.
Rudolph Alfred R.
Tuthill Cynthia W.
Gupta Anish
Rothwell Figg Ernst & Manbeck P.C.
SciClone Pharmaceuticals Inc.
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