Thymidine kinase negative insertion mutants of pseudorabies viru

Details Thymidine kinase negative insertion mutants of pseudorabies viru Thymidine kinase negative insertion mutants of pseudorabies viru

1986-04-29

1991-03-12

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4351721, 4351723, 4353201, 435 691, 435 701, 435 703, 935 22, 935 23, 935 32, 935 52, 935 57, 935 65, 935 63, C12P 2100, C12N 1500, C12N 700

Patent

active

049992961

ABSTRACT:
The present invention relates to pseudorabies viruses which fail to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene, vaccines against pseudorabies containing the same, and methods for the production and use of the same. The present invention also relates to pseudorabies virus based viral vectors for the coexpression of foreign genes.

REFERENCES:
patent: 4609548 (1986-09-01), Kit et al.
patent: 4680176 (1987-07-01), Berns et al.
patent: 4711850 (1987-12-01), Kit et al.
patent: 4753884 (1988-01-01), Kit et al.
patent: 4769331 (1988-09-01), Roizman et al.
Mettenleiter et al., (1985), J. Virology 56: 307-311.

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