Thymidine kinase deletion mutants of bovine herpesvirus-1, vacci

Details Thymidine kinase deletion mutants of bovine herpesvirus-1, vacci Thymidine kinase deletion mutants of bovine herpesvirus-1, vacci

1987-07-28

1989-04-25

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

435236, 4351721, 935 65, A61K 3912

Patent

active

048246670

ABSTRACT:
Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhinotracheitis. This invention also relates to methods for the production and use of the same.

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Qavi et al, Abst. Annu. Meet Am. Soc. Microbiol. 83, "Isolation of Thymidine Kinase Negative Infectious Bovine Rhinotracheitis Virus Mutants", 1983.

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