Thymidine kinase deletion mutants of bovine herpesvirus-1

Details Thymidine kinase deletion mutants of bovine herpesvirus-1 Thymidine kinase deletion mutants of bovine herpesvirus-1

1985-11-12

1987-10-27

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Inactivation or attenuation; producing viral subunits

4351721, 424 89, 935 65, C12N 704, C12N 1500, A61K 3912

Patent

active

047030119

ABSTRACT:
Bovine herpesvirus type 1 (infectious bovine rhinotracheitis virus) mutants which fail to produce any functional thymidine kinase as a result of a deletion in the thymidine kinase gene. The deletion in the thymidine kinase gene attenuates the viruses so that they can be used as an active agent in a modified live-virus vaccine against infectious bovine rhinotracheitis. This invention also relates to methods for the production and use of the same.

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