Thrombus specific conjugates

Details Thrombus specific conjugates Thrombus specific conjugates

1989-11-15

1991-04-30

Doll, John

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

424 9463, 424 9464, 435 13, 435183, 435215, 435216, 514 2, 514 12, 530300, 530324, 530345, 530350, A61K 3702, A61K 3748, A61K 37547

Patent

active

050116860

ABSTRACT:
Disclosed is a method of targeting reagents to the locus of a clot, and a family of substances that have affinity for fibrin. The method and substances exploit the discovery that the binding sites on protein A from Staphylococcus aureus have a significant affinity for fibrin. These fragments, analogs thereof, and oligomers of the fragments or analogs, may be attached to fibrinolytic enzymes, remotely detectable radiation emitting moieties, or healing agents to produce reagents which have affinity for the site of a wound or intravascular clot where fibrin has been deposited. Constructs comprising repeats of truncated analogs of the binding domain have low affinity for circulating immunoglobulin and high affinity for fibrin.

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