Thrombus imaging agents

Details Thrombus imaging agents Thrombus imaging agents

1998-08-27

2000-07-04

Dees, Jose' G.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

530300, 530317, A61K 5108, A61K 3812

Patent

active

060834811

ABSTRACT:
This invention relates to radiolabeled reagents that are scintigraphic imaging agents for imaging sites of thrombus formation in vivo, and methods for producing such reagents. Specifically, the invention relates to reagents each comprised of a specific binding compound, capable of binding to at least one component of a thrombus, covalently linked to a radiolabel-binding moiety. The invention provides these reagents, methods and kits for making such reagents, and methods for using such reagents labeled with technetium-99m to image thrombus sites in a mammalian body.

REFERENCES:
patent: 5443816 (1995-08-01), Zamora et al.
patent: 5785948 (1998-07-01), Itaya et al.
patent: 5843402 (1998-12-01), Stuttle
patent: 5879657 (1999-03-01), DeGrado et al.
patent: 5888970 (1999-03-01), Rajopadhye et al.

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