Thromboxane synthase inhibitors as insulin lowering agents and a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514256, A61K 3138, A61K 31505

Patent

active

047313633

ABSTRACT:
The present disclosure relates to the use of thromboxane synthase inhibitors as antiobesity agents and insulin lowering agents. Such compounds fall into a variety of classes among which are 1-substituted imidazoles, 4-substituted imidazoles, 3-substituted pyridines, 3-substituted indoles, 4-substituted pyrimidines, 5-substituted tetrazoles, pyrazolidines, quinazolines, and substituted xanthene carboxylic acids.

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patent: 3867539 (1975-02-01), Henkin
patent: 3880871 (1975-04-01), Haugwitz et al.
patent: 3991201 (1976-11-01), Heeres et al.
patent: 3996366 (1976-12-01), Baker et al.
Chem. Abst. 82:118,787(h) (1975)-Aeberli et al.
Chem. Abst. 74:96456(e) (1971)-Lefebvre et al.
Chem. Abst. 76:108,708(v) (1972)-Malaisse.
The Merck Index, 9th ed., item 4845-1976-Meader Co., Diabetologia 4, 370-374 (1968).

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