Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-05-13
1997-07-22
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31335
Patent
active
056504314
ABSTRACT:
A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral hemorrhage and asthma which comprises administering to a mammal suffering therefrom a therapeutically effective amount of a thromboxane ligand which is a compound formula I, ##STR1## wherein A, B, X, Y, and Z are defined in the specification.
REFERENCES:
patent: 4599353 (1986-07-01), Bito
patent: 4994274 (1991-02-01), Chan et al.
patent: 5034413 (1991-07-01), Chan et al.
patent: 5416106 (1995-05-01), Burk et al.
Starr. M.S., "Further Studies on the Effect of Prostalgnadin on Intraocular Pressure in the Rabbit", Exp. Eye Research, 1971, 11, pp. 170-177.
Bito, L.Z., "Prostaglandins, Other Eicosanoids, and Their Derivatives as Potential Antiglaucoma Agents," Applied Pharmacology in the Medical Treatment of Glaucomas Drance, S.M. and Neufeld, A.H. eds., New York, Grune & Stratton, 1984, pp. 477-505.
Nilsson, et.al., "PGF.sub.2.alpha. Increases Uveoscleral Outflow", Invest. Ophthalmol. Vis. Sci. (suppl), 284, 1987.
Siebold, et.al., "Esterified prostaglandin shows `potent` promise", Prodrug 5 3, 1989.
Bito, L.Z., "Prostaglandins, Old Concepts and New Perspectives", Arch. Ophthalmol. 105, 1036, 1987.
Coleman, R.A., et al., Comparison of the Actions of U-46619, A Prostaglandin H2-Analogue, with Those of Prostaglandin H2 and Thromboxane A2 on some isolated Br. J. Pharmacol 73:773-778 (1981).
Burk et al, Tetrahedron Letters (1993), 34(3), 395-8.
Burk Robert M.
Krauss Achim H.
Woodward David F.
Allergan
Baran Robert J.
Lambert Howard R.
Peabody, III John D.
Richter Johann
LandOfFree
Thromboxane ligands without blood clotting side effects does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Thromboxane ligands without blood clotting side effects, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thromboxane ligands without blood clotting side effects will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1560290