Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-09-28
2000-07-18
Seaman, D. Margaret
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514451, 514453, 549228, 549463, A61K 31335, A61K 3135, C07D32100, C07D30700
Patent
active
060908459
ABSTRACT:
A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, and asthma which comprises administering to a mammal suffering therefrom a therapeutically effective amount of a thromboxane ligand which is a compound formula I, ##STR1## wherein Y is (CH.sub.2).sub.x ; Z is selected from the group consisting of O, OCH.sub.2, ##STR2## and (CR.sub.2).sub.x, x is an integer of 1 or 2; R.sub.2 is hydrogen or an alkyl radical of from 1 to 4 carbons, A is an alkylene or alkenylene radical having from two to seven carbon atoms, which radical may be substituted with one or more hydroxy, oxo, alkyloxy or alkylcarboxy groups or said alkylene or alkenylene may have one or more enchained oxo or imino radicals; B is a methyl radical or a cycloalkyl radical having from three to seven carbon atoms, or an aryl radical, selected from the group consisting of hydrocarbyl aryl and heteroaryl radicals wherein the heteroatom is selected from the group consisting of nitrogen, oxygen and sulfur atoms, or substituted derivatives of said methyl, cycloalkyl or aryl radicals wherein said substituent is selected from the group consisting of halo, nitro, amino, thiol, hydroxy, alkyloxy and alkylcarboxy; and X is selected from the group consisting of cyano, --COOR, --CH.sub.2 OR, --C(O)N(R.sub.2), --CH.sub.2 N(R.sub.2) --CH.dbd.N--OH and --CH.sub.2 SR.sub.1 radicals wherein R is hydrogen or a C.sub.1 to C.sub.10 alkyl, phenyl or benzyl and E is O or S; or a pharmaceutically acceptable salt thereof.
REFERENCES:
patent: 4591603 (1986-05-01), Das
patent: 5650431 (1997-07-01), Burk
patent: 5741812 (1998-04-01), Burk
Burk Robert M.
Krauss Achim H.
Woodward David F.
Allergan Sales Inc.
Baran Robert J.
Fisher Carlos A.
Seaman D. Margaret
Voet Martin A.
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