Thromboxane A.sub.2 antagonists and pharmaceutical compositions

Details Thromboxane A.sub.2 antagonists and pharmaceutical compositions Thromboxane A.sub.2 antagonists and pharmaceutical compositions

1988-12-13

1990-11-27

Lone, Werren B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

560 16, 562401, 562427, A61K 31195, C07C32349

Patent

active

049736043

ABSTRACT:
This invention relates to several thromboxane A.sub.2 inhibiting 7-[3-.alpha.-[1-[[(phenylamino)-thioxomethyl]hydrazono]ethyl]-bicyclo[2.2. 1]-heptenoic acids, pharmaceutical compositions employing them and methods of their use.

REFERENCES:
patent: 4416896 (1983-11-01), Nakane et al.
patent: 4456617 (1984-06-01), Nakane et al.
patent: 4596823 (1986-06-01), Jones et al.
Armstrong et al., Br. J. Pharmac. (1985), V. 84, pp. 595-607.
Wilson et al, Advances in Pros., Throm. & Leukotriene Res., vol. 14, (1985), pp. 393-425.
Nakane et al, Advances in Pros., Throm. & Leukotriene Res., (1985), vol. 15, p. 291.
Sprague et al, Advances in Pros., Throm. & Leukotriene Res., (1980), vol. 6, pp. 493-496.

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