Thrombospondin receptor binding peptides

Details Thrombospondin receptor binding peptides Thrombospondin receptor binding peptides

1993-03-05

1995-03-21

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

530328, 530329, 530330, A61K 3702

Patent

active

053996674

ABSTRACT:
Novel short peptides are disclosed that bind to the thrombospondin 1 receptor, which preferably have 5-13 amino acid residues which share the tripeptide Val-Val-Met and have the following sequences: RFYVVMWKQVTQS (Seq ID No. 1) and fragments thereof containing the minimal sequence RFYVVM, (Seq ID No. 3) and FIRVVMYEGKK (Seq ID No. 4) and fragments thereof containing the minimal sequence IRVVM (Seq ID No. 5).

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patent: 5190920 (1993-03-01), Baltimore et al.
patent: 5192744 (1993-03-01), Bouck et al.
patent: 5200397 (1993-04-01), Deutch et al.
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Kosfeld et al., J. Biol. Chem. 266, pp. 24257-24259 (1991).
Dixit et al., Proc. Natl. Acad. Sci. 82, 3472-3476 (1985).

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