Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-04-21
2010-02-02
Harris, Alana M (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S004000, C436S063000, C436S064000, C436S086000, C436S174000, C436S177000
Reexamination Certificate
active
07655411
ABSTRACT:
The invention relates to thrombospondin fragments found in plasma, their use or use of portions thereof in diagnostic methods, as method calibrators, method indicators, and as immunogens, and as analytes for methods with substantial clinical utility; and their detection in plasma or other bodily fluids for purpose of diagnostic methods, especially for cancer.
REFERENCES:
patent: 4610960 (1986-09-01), Mosher
patent: 4820505 (1989-04-01), Ginsberg et al.
patent: 5192744 (1993-03-01), Bouck et al.
patent: 5256538 (1993-10-01), Aiken et al.
patent: 5654277 (1997-08-01), Eyal et al.
patent: 5686583 (1997-11-01), Bosslet et al.
patent: 5750502 (1998-05-01), Jessell et al.
patent: 5753517 (1998-05-01), Brooks et al.
patent: 5770563 (1998-06-01), Roberts
patent: 5840507 (1998-11-01), Fruehauf
patent: 5840692 (1998-11-01), Deutch et al.
patent: 6051549 (2000-04-01), Roberts et al.
patent: 6239110 (2001-05-01), Eyal et al.
patent: 6339062 (2002-01-01), Williams et al.
patent: 2001/0041670 (2001-11-01), Simantov et al.
patent: 2002/0197697 (2002-12-01), Abdelouahed et al.
patent: 2003/0119074 (2003-06-01), Jackowski
patent: 2003/0166017 (2003-09-01), McCarthy
patent: 2003/0180295 (2003-09-01), Tuszynski et al.
patent: WO9807035 (1998-02-01), None
patent: WO 01/05968 (2001-01-01), None
Lawler JW et al. Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. J. Biol. Chem., 1978. 253(23):8609-8616. (Abstract only).
Wallinder L et al. Rapid removal to the liver of intravenously injected lipoprotein lipase. Biochem. Biophys. Acta, Oct. 26, 1979; 575(1):166-173. (Abstract only).
Margossian SS et al. Physical characterization of platelet thrombospondin. J. Biol. Chem., 1981. 256(14):7495-7500, (Abstract only).
Saglio SD et al. Use of a radioimmunoassay to quantify thrombospondin. Blood, Jan. 1982; 59(1):162-166. (Abstract only).
Mosher DF et al. Synthesis and secretion of thrombospondin by cultured human endothelial cells. J. Cell Biol., 1982. 93(2):343-348.
Dawes J et al. A radioimmunoassay for thrombospondin, used in a comparative study of thrombospondin, beta-thromboglobulin and platelet factor 4 in healthy volunteers. Thromb. Res., Mar. 15, 1983; 29:569-581.
Jaffe EA et al. Cultured human fibroblasts synthesize and secrete thrombospondin and incorporate it into extracellular matrix. Proc. Natl. Acad. Sci., USA, Feb. 1983; 80(4):998-1002.
Prowse CV et al. A comparative study using immunological and biological assay of the haemostatic responses to DDAVP infusion venous occlusion and exercise in normal men. Thromb. Haemost., Feb. 28, 1984; 51(1):110-114. (Abstract only).
Mumby SM et al. Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen. J. Cell Biol., 1984. 98(2):646-652. (Abstract only).
Coligan, JE and Slayter HS. Structure of thrombospondin. J. Biol. Chem., 1984. 259:3944-3948.
Dixit VM et al. Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin. J Biol Chem, 1984. 259:10100-10105. (Abstract only).
Lane DA et al. Detection of enhanced in vivo platelet alpha-granule release in different patient groups—comparison of beta-thromboglobulin, platelet factor 4 and thrombospondin assays. Thromb. Haemost., Oct. 31, 1984; 52(2):183-187. (Abstract only).
Lahav J et al. Thrombospondin interactions with fibronectin and fibrinogen. Mutual inhibition in binding. Eur. J. Biochem., Nov. 15, 1984; 145(1):151-156. (Abstract only).
Silverstein RL et al. Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. J. Clin. Invest., Nov. 1984; 74(5):1625-1633. (Abstract only).
Lawler J et al. The structure of human platelet thrombospondin. J. Biol. Chem., 1985. 260:3762-3772.
Roberts DD et al. Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence. Nature, 1985. 318(6041):64-66. (Abstract only).
Jaffe EA et al. Monocytes and macrophages synthesize and secrete thrombospondin. Blood, Jan. 1985; 65(1):79-84. (Abstract only).
Dixit VM et al. Effects of anti-thrombospondin monoclonal antibodies on the agglutination of erythrocytes and fixed, activated platelets by purified thrombospondin. Biochemistry, Jul. 30, 1985; 24(16):4270-4275.
Silverstein RL et al. Activation of immobilized plasminogen by tissue activator. Multimolecular complex formation. J. Biol. Chem., 1985. 260(18):10346-10352.
Galvin NJ et al. Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electon microscopy and high sensitivity amino acid sequencing. J. Cell Biol., 1985. 101(4):1434-1441.
Trzeciak MC et al. Plasma thrombospondin in patients with chronic renal failure, liver disease and splenectomy. Thromb. Res., Oct. 1, 1985; 40(1):121-128. (Abstract only).
Tuszynski GP et al. The interaction of human platelet thrombospondin with fibrinogen. Thrombospondin purification and specificity of interaction. J. Biol. Chem., 1985. 260(22):12240-12245.
Miller WR et al. Platelet-associated proteins in human breast cyst fluids. Clin. Chim. Acta, Oct. 31, 1985; 152(1-2):37-42. (Abstract only).
Switalska HI et al. Radioimmunoassay of human platelet thrombospondin: different patterns of thrombospondin and beta-thromboglobulin antigen secretion and clearance from the circulation. J. Lab. Clin. Med., Dec. 1985; 106(6):690-700. (Abstract only).
Kaplan KL et al. Plasma levels of platelet secretory proteins. Crit. Rev. Oncol. Hematol., 1986. 5(3):235-255. (Abstract only).
Dixit VM et al. Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes. J. Biol. Chem., 1986, 261(4):1962-1968.
Wolff R et al. Interaction of thrombospondin with resting and stimulated human platelets. J. Biol. Chem., 1986. 261(15):6840-6846.
Kao KJ et al. A monoclonal antibody-based enzyme-linked immunosorbent assay for quantitation of plasma thrombospondin. Am. J. Clin. Pathol., Sep. 1986; 86(3):317-323. (Abstract only).
Frazier WA. Thrombospondin: a modular adhesive glycoprotein of platelets and nucleated cell. J. Cell Biol., 1987. 105(2):625-632.
Asch AS et al. Isolation of the thrombospondin membrane receptor. J. Clin. Invest., Apr. 1987; 79:1054-1076. (Abstract only).
Galvin NJ et al. Interaction of human thrombospondin with types I-V collagen: direct binding and electron microscopy. J. Cell Biol., 1987. 104(5):1413-1422. (Abstract only).
Dardik R et al. The structure of endothelial cell thrombospondin. Characterization of the heparin-binding domains. Eur. J. Biochem., Oct. 15, 1987; 168(2):347-355. (Abstract only).
McCrohan MB et al. Plasma thrombospondin as an indicator of intravascular platelet activation in patients with vasculitis. Thromb. Haemost., Oct. 28, 1987; 58(3):850-852. (Abstract only).
Legrand C et al. Use of a monoclonal antibody to measure the surface expression of thrombospondin following platelet activation. Eur. J. Biochem., Jan. 15, 1988; 171(1-2):393-399. (Abstract only).
Majack RA et al. Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation. J. Cell Biol. Feb. 1988; 106:415-422.
Dawes J et al. Do extra-platelet sources contribute to the plasma level of thrombospondin? Thromb. Haemost., Apr. 8, 1988; 59(2):273-276. (Abstract only).
Clezardin P et al. Complex formation of human thrombospondin with osteonectin. Eur. J. Biochem., Aug. 1, 1988; 175:275-284. (Abstract only).
Asch AS and Nachman RL. Thrombospondin: phenomenology to function. Prog. Hemost. Thromb., 1989. 9:157-176. (Abstract only).
Gehron-Robey P et al. Thrombospondin is an osteoblast-derived component of mineralized extracellular matrix. J. Cell Biol., 1989. 108:719-727.
Cardin AD and Weintraub HJ. Molecular modeling of protein-glycosaminoglycan interactions. Arteriosclerosis, Jan.-Feb. 1989; 9(1):21-32. (Abstract only).
Bacon-Baguley T et al. Thrombospondin binding to specific sequences within the Aα- and Bβ-chains of fibrinogen. J. Biol. Chem., 1990. 265(4):2317-23.
Silverstein RL et al. T
Caesar Rivise Bernstein Cohen & Pokotilow Ltd.
Harris Alana M
W2 Holdings, Inc.
LandOfFree
Thrombospondin fragments and binding agents in the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Thrombospondin fragments and binding agents in the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thrombospondin fragments and binding agents in the... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4219815