Thrombosis prophylaxis for factor V.sup.LEIDEN carriers

Details Thrombosis prophylaxis for factor V.sup.LEIDEN carriers Thrombosis prophylaxis for factor V.sup.LEIDEN carriers

1996-05-08

1999-11-02

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 12, 435 13, 530300, 530350, A01N 3718, A61K 3800, C12Q 156

Patent

active

059770570

ABSTRACT:
Persons having the Factor V.sup.LEIDEN mutation and a lower than average plasma level of TFPI have been found to be at elevated risk of thrombosis. Prophylactic methods for reducing the risk of thrombosis employ the administration of TFPI to achieve higher levels in the plasma.

REFERENCES:
Kalafatis et al., "Characterization of the Molecular Defect in Factor V.sup.R506Q ", J. Biol. Chem., 270(8):4053-4057 (1995).
Novotny et al., "Plasma Antigen Levels of the Lipoprotein-Associated Coagulation Inhibitor in Patient Samples", Blood 78(2):387-393 (1991).
Bertina et al. Nature 369:64-67, 1994.
Hamamoto et al. J. Biol. Chem 268(12):8704-8710, 1993.
Katzung, Basic & Clinical Pharmacology. Appleton & Lange. pp. 464-467, 1992.
van't Veer, C., and Mann, K.G., (1995) Blood 86 suppl. 1, 448a, abstract 1777.
van't Veer, C., Kalafatis, M., and Mann, K.G. (1995) Blood 86 suppl. 1, 285a, abstract 1128.
van't Veer, C. et al., The Journal of Biological Chemistry "Increased Tissue Factor-initiated Prothrombin Activation as a Result of the Arg.sup.506 .fwdarw. Gln Mutation in Factor V.sup.LEIDEN " vol. 272, No. 33, Aug. 15, 1997 pp. 20721-20729.
van't Veer, C. et al., The Journal of Biological Chemistry "Inhibitory Mechanism of the Protein C. Pathway on Tissue Factor-induced Thrombin Generation" vol. 272, No. 12, Mar. 21, 1997, pp. 7983-7994.

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