Thromboresistant surface treatment for biomaterials

Details Thromboresistant surface treatment for biomaterials Thromboresistant surface treatment for biomaterials

1994-09-16

1996-11-26

Hoke, Veronica P.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Stent structure

523112, 523113, 523114, 523115, 524 29, 623 2, 623 6, A61F 206, A61F 216, C08L 508

Patent

active

055780733

ABSTRACT:
A biomaterial with a thromboresistant surface and a method for forming same are provided. The thromboresistant surface is comprised of a distinct coating layer of a chitosan-based membrane and a biologically active material. The biologically active material is capable of converting the chitosan membrane coating from a highly thrombogenic to an essentially non-thrombogenic one. The biologically active material can be a polymeric substance, such as polyvinyl alcohol, forming a polymeric blend with the chitosan, or, can be a biological substance, such as serum albumin, embedded in or attached to the chitosan membrane which has been activated with a treatment of glutardialdehyde. The thromboresistant biomaterial is suitable for use in vascular grafts having an inside diameter of less than 6 millimeters.

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