Thromboresistant coating

Details Thromboresistant coating Thromboresistant coating

1990-11-08

1991-10-01

Isabella, David J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Stent structure

623 66, 604266, 128DIG21, 523112, 427 2, A61F 206

Patent

active

050530488

ABSTRACT:
A thromboresistant coating, method for forming same on a medical device, and the medical device thus prepared are provided. The thromboresistant coating is a highly cross-linked three-dimensional matrix copolymerized from an aminosilane component and a silane other than the aminosilane that is cured and dried into a thick matrix having amino groups interspersed therethroughout. The amino groups facilitate attachment of an antithrombogenic agent to the matrix and thus to the medical device. In addition, an antithrombogenic material is secured to the aminosilane copolymeric matrix.

REFERENCES:
patent: 3434869 (1969-03-01), Davidson
patent: 3639141 (1972-02-01), Dyck
patent: 3708324 (1973-01-01), Stebleton
patent: 3844989 (1974-10-01), Harumiya et al.
patent: 3846353 (1974-11-01), Grotta
patent: 4521564 (1985-06-01), Solomon et al.
patent: 4600613 (1986-07-01), Yoshida
patent: 4820302 (1989-04-01), Woodroof
patent: 4851009 (1989-07-01), Pinchuk
patent: 4906465 (1990-03-01), Chaikof et al.
Larm et al., "A New Non-Thrombogenic Surface Prepared by Selective Covalent Binding of Heparin Via a Modified Reducing Terminal Residue," Biomat., Med. Dev., Art. Org., 11 (2&3), 161-173, 1983.

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